The primary regulators of metazoan gene expression are enhancers, originally functionally
defined as DNA sequences that can activate transcription at promoters in an orientation …

Cohesin folds mammalian interphase chromosomes by extruding the chromatin fiber into
numerous loops.“Loop extrusion” can be impeded by chromatin-bound factors, such as …

The genetic material in human cells is continuously exposed to a wide variety of insults that
can induce different DNA lesions. To maintain genomic stability and prevent potentially …

DNA double strand breaks (DSBs) are common lesions whose misrepair are drivers of
oncogenic transformations. The non-homologous end joining (NHEJ) pathway repairs the …

3D chromatin organization plays a critical role in regulating gene expression, DNA
replication, recombination, and repair. While initially discovered for its role in sister …

Cohesin, a crucial regulator of genome organisation, plays a fundamental role in
maintaining chromatin architecture as well as gene expression. Among its subunits, STAG2 …

DNA double-strand breaks (DSBs) must be repaired to ensure genome stability. Crucially,
DSB-ends must be kept together for timely repair. In Saccharomyces cerevisiae, two …

Efficient repair of DNA double-strand breaks in the Ig heavy chain gene locus is crucial for B-
cell antibody class switch recombination (CSR). The regulatory dynamics of the repair …

Enhancers possess both structural elements mediating promoter loo** and functional
elements mediating gene expression. Traditional models of enhancer-mediated gene …

Compartmentalizing damaged DNA: A double-edged sword: Molecular Cell Skip to Main
Content Advertisement Molecular Cell This journal offers authors two options (open access or …