The mammalian brain contains unusually high levels of d‐serine, ad‐amino acid previously
thought to be restricted to some bacteria and insects. In the last few years, studies from …

The de novo synthesis of the amino acid l-serine plays an essential role in the development
and functioning of the central nervous system (CNS). l-Serine displays many metabolic …

d-Amino acids are increasingly being recognized as important signaling molecules in
mammals, including humans. d-Serine and d-aspartate are believed to act as signaling …

d-Serine is a unique endogenous substance enriched in the brain at the exceptionally high
concentrations as a free d-amino acid in mammals throughout their life. Peripheral tissues …

Dementia, of which Alzheimer's disease (AD) is the most common form, is characterized by
progressive cognitive deterioration, including profound memory loss, which affects …

The orphan glutamate-like receptor GluRδ2 is predominantly expressed in Purkinje cells of
the central nervous system. The classification of GluRδ2 to the ionotropic glutamate receptor …

In mammalian brain, d-serine is synthesized from l-serine by serine racemase, and it
functions as an obligatory co-agonist at the glycine modulatory site of N-methyl-d-aspartate …

We present the first two identified cases of phosphoserine aminotransferase deficiency. This
disorder of serine biosynthesis has been identified in two siblings who showed low …

l-Serine is the immediate precursor of d-serine, a major agonist of the N-methyl-d-aspartate
(NMDA) receptor. l-Serine is a pivotal amino acid since it serves as a precursor to a large …

Nonketotic hyperglycinemia (NKH) is caused by deficient glycine cleavage enzyme activity
and characterized by elevated brain glycine. Metabolism of glycine is connected …