Randomized clinical trials (RCT) are accepted as the gold-standard approaches to measure
effects of intervention or treatment on outcomes. They are also the designs of choice for …

Objectives Motivated by recent calls to use electronic health records for research, we
reviewed the application and development of methods for addressing the bias from …

Significantly revised, the fifth edition of the most complete, accessible text now covers all
three approaches to structural equation modeling (SEM)--covariance-based SEM …

Importance Anticoagulant choice and proton pump inhibitor (PPI) cotherapy could affect the
risk of upper gastrointestinal tract bleeding, a frequent and potentially serious complication …

Biobanks linked to electronic health records provide rich resources for health‐related
research. With improvements in administrative and informatics infrastructure, the availability …

It has become clear that early life (including in utero exposures) is a key window of
vulnerability during which environmental exposures can alter developmental trajectories …

Background: Amiodarone, the most effective antiarrhythmic drug in atrial fibrillation, inhibits
apixaban and rivaroxaban elimination, thus possibly increasing anticoagulant-related risk …

Abstract Electronic Health Records (EHR) are increasingly being perceived as a unique
source of data for clinical research as they provide unprecedentedly large volumes of real …

Observational pharmacoepidemiological studies using routinely collected healthcare data
are increasingly being used in the field of nephrology to answer questions on the …

Vaso-occlusive episodes (VOEs) are a major concern in patients with sickle cell disease
(SCD). Exposure to systemic corticosteroids has been suspected to increase the occurrence …