Acute and post-acute neuromodulation induces stroke recovery by promoting survival signaling, neurogenesis, and pyramidal tract plasticity

AB Caglayan, MC Beker, B Caglayan… - Frontiers in cellular …, 2019 - frontiersin.org
Repetitive transcranial magnetic stimulation (rTMS) has gained interest as a non-invasive
treatment for stroke based on the data promoting its effects on functional recovery. However …

Statin use and outcomes of patients with acute ischemic stroke treated with intravenous thrombolysis: a systematic review and meta-analysis

Y Guo, X Guo, K Zhao, Q Bao, J Yang… - Frontiers in …, 2021 - frontiersin.org
Background: The data on the relationship between statin use and clinical outcomes after
intravenous thrombolysis (IVT) for acute ischemic stroke (AIS) are in controversy. Objective …

Mevalonate cascade and neurodevelopmental and neurodegenerative diseases: future targets for therapeutic application

X Jiao, N Ashtari, M Rahimi-Balaei… - Current Molecular …, 2017 - ingentaconnect.com
The mevalonate cascade is a key metabolic pathway that regulates a variety of cellular
functions and is thereby implicated in the pathophysiology of most brain diseases, including …

Post-acute delivery of memantine promotes post-ischemic neurological recovery, peri-infarct tissue remodeling, and contralesional brain plasticity

Y Wang, EH Sanchez-Mendoza… - Journal of Cerebral …, 2017 - journals.sagepub.com
The NMDA antagonist memantine preferentially inhibits extrasynaptic NMDA receptors,
which are overactivated upon stroke and thought to disturb neuroplasticity. We hypothesized …

[HTML][HTML] Post-ischemic protein restriction induces sustained neuroprotection, neurological recovery, brain remodeling, and gut microbiota rebalancing

TS de Carvalho, V Singh, AM Yusuf, J Wang… - Brain, Behavior, and …, 2022 - Elsevier
Background Moderate dietary protein restriction confers neuroprotection when applied
before ischemic stroke. How a moderately protein-reduced diet influences stroke recovery …

Lentivirally administered glial cell line-derived neurotrophic factor promotes post-ischemic neurological recovery, brain remodeling and contralesional pyramidal tract …

M Beker, AB Caglayan, MC Beker, S Altunay… - Experimental …, 2020 - Elsevier
Owing to its potent longterm neuroprotective and neurorestorative properties, glial cell line-
derived neurotrophic factor (GDNF) is currently studied in neurodegenerative disease …

The Unconventional Growth Factors Cerebral Dopamine Neurotrophic Factor and Mesencephalic Astrocyte–Derived Neurotrophic Factor Promote Post-ischemic …

AB Caglayan, MC Beker, E Sertel Evren… - Translational stroke …, 2023 - Springer
Considerable efforts are currently made to develop strategies that boost endogenous
recovery once a stroke has occurred. Owing to their restorative properties, neurotrophic …

Vinpocetine Ameliorates Neuronal Injury After Cold-Induced Traumatic Brain Injury in Mice

HE Yelkenci, Z Degirmenci, HI Koc, S Bayirli… - Molecular …, 2025 - Springer
Traumatic brain injury (TBI), also known as intracranial injury, is a common condition with
the highest incidence rate among neurodegenerative disorders and poses a significant …

Lithium promotes long-term neurological recovery after spinal cord injury in mice by enhancing neuronal survival, gray and white matter remodeling, and long …

Z Balçıkanlı, I Culha, P Dilsiz, MS Aydin… - Frontiers in Cellular …, 2022 - frontiersin.org
Spinal cord injury (SCI) induces neurological deficits associated with long-term functional
impairments. Since the current treatments remain ineffective, novel therapeutic options are …

Early treatment with atorvastatin exerts parenchymal and vascular protective effects in experimental cerebral ischaemia

C Potey, T Ouk, O Petrault, M Petrault… - British journal of …, 2015 - Wiley Online Library
Background and Purpose From the clinical and experimental data available, statins appear
to be interesting drug candidates for preventive neuroprotection in ischaemic stroke …