Next-generation metabolic engineering approaches towards development of plant cell suspension cultures as specialized metabolite producing biofactories

SS Arya, JE Rookes, DM Cahill, SK Lenka - Biotechnology Advances, 2020 - Elsevier
Plant cell suspension culture (PCSC) has emerged as a viable technology to produce plant
specialized metabolites (PSM). While Taxol® and ginsenoside are two examples of …

Advances in ethnobotany, synthetic phytochemistry and pharmacology of endangered herb Picrorhiza kurroa (Kutki): A comprehensive review (2010-2020)

S Mehta, AK Sharma, RK Singh - Mini reviews in medicinal …, 2021 - ingentaconnect.com
Picrorhiza kurroa Royle ex Benth.(Family: Plantaginaceae) is a well-recognized Ayurvedic
herb. It is commonly called “Kutki” or “Kurro” and 'Indian gentian'. Iridoid glycosides are the …

Endomicrobiome of in vitro and natural plants deciphering the endophytes-associated secondary metabolite biosynthesis in Picrorhiza kurrooa, a Himalayan …

A Tamang, M Swarnkar, P Kumar, D Kumar… - Microbiology …, 2023 - Am Soc Microbiol
Picrorhiza kurrooa an endangered high-altitude Himalayan medicinal herb, is used as a
potent hepatoprotective due to the presence of various secondary metabolites, with …

Integration of biotechnological approaches for the production of phenylethanoids and phenylpropanoids in in vitro cultures of Rhodiola sp. a comprehensive review

S Rattan, AR Warghat - Industrial Crops and Products, 2023 - Elsevier
Rhodiola L. is an herbaceous medicinal plant in the Crassulaceae family. Its raw extract,
leaves, and roots have been used widely in traditional folk medicine in Asia and Europe …

Iridoid glycosides from Picrorhiza genus endemic to the Himalayan region: phytochemistry, biosynthesis, pharmacological potential and biotechnological …

T Sharma, Anmol, U Sharma… - Critical Reviews in …, 2024 - Taylor & Francis
Iridoid glycosides are monoterpenoids synthesized in several plant species known to exhibit
a diverse range of pharmacological activities. They are used as important bioactive …

Modular design of picroside-II biosynthesis deciphered through NGS transcriptomes and metabolic intermediates analysis in naturally variant chemotypes of a …

V Kumar, A Bansal, RS Chauhan - Frontiers in Plant Science, 2017 - frontiersin.org
Picroside-II (P-II), an iridoid glycoside, is used as an active ingredient of various commercial
herbal formulations available for the treatment of liver ailments. Despite this, the knowledge …

Comparative transcriptome analysis in different tissues of a medicinal herb, Picrorhiza kurroa pinpoints transcription factors regulating picrosides biosynthesis

I Vashisht, T Pal, H Sood, RS Chauhan - Molecular biology reports, 2016 - Springer
Transcriptional regulation of picrosides biosynthesis, the iridoid glycosides of an
endangered medicinal herb, Picrorhiza kurroa, is completely unknown. P. kurroa plants …

[HTML][HTML] Production of medicinal compounds from endangered and commercially important medicinal plants through cell and tissue culture technology for herbal …

H Sood - Bioactive Compounds in Nutraceutical and Functional …, 2020 - intechopen.com
Plant cell culture technologies have made possible the production of a wide variety of
pharmaceuticals such as alkaloids, terpenoids, steroids, saponins, monoterpenes …

[HTML][HTML] A comprehensive review of in vitro precursor feeding strategies for the overproduction of high-value plant secondary metabolites

MRN Ramadani, N Jadid - Arabian Journal of Chemistry, 2024 - Elsevier
Plant tissue culture techniques have revolutionized various aspects of modern agriculture,
horticulture, and pharmaceutical industries. This method contributes to enhancing the …

Spectral light treatment and exogenous feeding of precursors enhanced the picrosides content in dedifferentiated cell culture of Picrorhiza kurroa

M Partap, A Kumar, P Kumar, D Kumar… - Biocatalysis and …, 2025 - Elsevier
The present investigation evaluates the impact of the light spectrum (red and blue) and
precursors treatment on picrosides (PI, P-II, P-III) and pathway precursors metabolites …