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Research progresses of targeted therapy and immunotherapy for hepatocellular carcinoma
T Wang, Q Zhang, N Wang, Z Liu… - Current Medicinal …, 2021 - benthamdirect.com
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide,
with nearly one million new cases and deaths every year. Owing to the complex …
with nearly one million new cases and deaths every year. Owing to the complex …
Strengthening molecular glues: design strategies for improving thalidomide analogs as cereblon effectors and anticancer agents
MJ Nutt, SG Stewart - Drug Discovery Today, 2024 - Elsevier
Highlights•SAR insights on minimum pharmacophore for CRBN binding.•Scaffold alterations
improving drug solubility and stability.•Rational approaches: phenotypic screening, target …
improving drug solubility and stability.•Rational approaches: phenotypic screening, target …
Protective effects of silymarin on triptolide-induced acute hepatotoxicity in rats
L Wang, QH Huang, YX Li… - Molecular …, 2018 - spandidos-publications.com
Silymarin has been used in the treatment of a number of liver diseases for a long time, but its
efficacy in preventing triptolide induced acute hepatotoxicity has not been reported …
efficacy in preventing triptolide induced acute hepatotoxicity has not been reported …
Novel 3-(pyrazol-4-yl)-2-(1H-indole-3-carbonyl)acrylonitrile derivatives induce intrinsic and extrinsic apoptotic death mediated P53 in HCT116 colon carcinoma
A novel series of α-cyano indolylchalcones was prepared, and their chemical structures
were confirmed based on the different spectral data. Among them, compound 7f was …
were confirmed based on the different spectral data. Among them, compound 7f was …
Design, synthesis and biological evaluation of the thioether-containing lenalidomide analogs with anti-proliferative activities
D **ao, Y Wang, X Hu, W Kan, Q Zhang, X Jiang… - European Journal of …, 2019 - Elsevier
Lenalidomide and its analogs have exhibited extensive anti-tumor, anti-inflammatory and
immunomodulatory properties in pharmaceutical research. In this work, a series of novel …
immunomodulatory properties in pharmaceutical research. In this work, a series of novel …
Design, synthesis and biological evaluation of thioether-containing lenalidomide and pomalidomide derivatives with anti-multiple myeloma activity
Y Wang, T Mi, Y Li, W Kan, G Xu, J Li, Y Zhou… - European Journal of …, 2021 - Elsevier
Lenalidomide and its analogs are well-known for treating multiple myeloma. In this work,
designed sulfide-modified lenalidomide and pomalidomide were synthesized and …
designed sulfide-modified lenalidomide and pomalidomide were synthesized and …
Synergistic effects of gefitinib and thalidomide treatment on EGFR-TKI-sensitive and-resistant NSCLC
X **a, Y Liu, Y Liao, Z Guo, C Huang, F Zhang… - European Journal of …, 2019 - Elsevier
EGF receptor tyrosine kinase inhibitors (EGFR-TKIs) have been widely used as a standard
therapy in non-small cell lung cancer (NSCLC) patients with EGFR mutations. However …
therapy in non-small cell lung cancer (NSCLC) patients with EGFR mutations. However …
Current discovery strategies for hepatocellular carcinoma therapeutics
Q Dai, C Zhang, Z Yuan, Q Sun… - Expert opinion on drug …, 2020 - Taylor & Francis
Introduction: The global incidence of hepatocellular carcinoma (HCC) is not expected to
decline significantly over the next 30 years. And although the latest gene sequencing …
decline significantly over the next 30 years. And although the latest gene sequencing …
Human amnion epithelial cells produce soluble factors that enhance liver repair by reducing fibrosis while maintaining regeneration in a model of chronic liver injury
A Hodge, N Andrewartha, D Lourensz… - Cell …, 2020 - journals.sagepub.com
Human amnion epithelial cells (hAECs) exert potent antifibrotic and anti-inflammatory effects
when transplanted into preclinical models of tissue fibrosis. These effects are mediated in …
when transplanted into preclinical models of tissue fibrosis. These effects are mediated in …
3-(1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives and uses thereof
REJ Beckwith, S Bonazzi, A Cernijenko… - US Patent …, 2019 - Google Patents
2019-02-14 Assigned to NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC.
reassignment NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. ASSIGNMENT …
reassignment NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC. ASSIGNMENT …