The myoD gene converts many differentiated cell types into muscle. MyoD is a member of
the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is …

The expression of Myod is sufficient to convert a fibroblast to a skeletal muscle cell, and, as
such, is a model system in developmental biology for studying how a single initiating event …

In this paper we present several web-based tools to identify conserved patterns in
sequences. In particular we present details on the functionality of PROMO version 2.0, a …

The c-fos serum response element (SRE) forms a ternary complex with the transcription
factors SRF (serum response factor) and TCF (ternary complex factor). By itself, SRF can …

The myogenic basic HLH transcription factor family of genes, composed of MyoD, myogenin,
Myf-5, and Myf-6, are thought to regulate skeletal muscle differentiation. To understand the …

Members of the myocyte enhancer factor-2 (MEFS) family of MADS domain transcription
factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the …

A technique was developed for studying protein-DNA recognition that can be applied to any
purified protein, partially purified protein, or cloned gene. From oligonucleotides in which …

Serum response factor (SRF) is a widely expressed transcription factor involved in
orchestrating disparate programs of gene expression linked to muscle differentiation and …

Serum response factor (SRF) regulates transcription of many serum-inducible and muscle-
specific genes. Using a functional screen, we identified LIM kinase-1 as a potent activator of …

In this report we provide four lines of evidence indicating that El2/E47-like proteins interact in
vivo with the myogenic HLH proteins MyoDand myogenin. First, cotransfection of MyoD and …