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The cell biology of synapse formation
TC Südhof - Journal of Cell Biology, 2021 - rupress.org
In a neural circuit, synapses transfer information rapidly between neurons and transform this
information during transfer. The diverse computational properties of synapses are shaped by …
information during transfer. The diverse computational properties of synapses are shaped by …
Towards an understanding of synapse formation
TC Südhof - Neuron, 2018 - cell.com
Synapses are intercellular junctions specialized for fast, point-to-point information transfer
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …
from a presynaptic neuron to a postsynaptic cell. At a synapse, a presynaptic terminal …
Synaptic neurexin complexes: a molecular code for the logic of neural circuits
TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlap** and interdigitated …
information, thereby connecting neurons into millions of overlap** and interdigitated …
Spine dynamics in the brain, mental disorders and artificial neural networks
In the brain, most synapses are formed on minute protrusions known as dendritic spines.
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Unlike their artificial intelligence counterparts, spines are not merely tuneable memory …
Neurexins: molecular codes for sha** neuronal synapses
The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …
their synapses. We propose that a substantial degree of synapse formation and function is …
Divergent midbrain circuits orchestrate escape and freezing responses to looming stimuli in mice
Animals respond to environmental threats, eg looming visual stimuli, with innate defensive
behaviors such as escape and freezing. The key neural circuits that participate in the …
behaviors such as escape and freezing. The key neural circuits that participate in the …
Fluid biomarkers for synaptic dysfunction and loss
E Camporesi, J Nilsson, A Brinkmalm… - Biomarker …, 2020 - journals.sagepub.com
Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …
neurons and stored for memory formation. Synaptic degeneration is a global and early …
A common thalamic hub for general and defensive arousal control
Y Wang, L You, KM Tan, M Li, J Zou, Z Zhao, W Hu, T Li… - Neuron, 2023 - cell.com
The expression of defensive responses to alerting sensory cues requires both general
arousal and a specific arousal state associated with defensive emotions. However, it …
arousal and a specific arousal state associated with defensive emotions. However, it …
Liprin-α proteins are master regulators of human presynapse assembly
The formation of mammalian synapses entails the precise alignment of presynaptic release
sites with postsynaptic receptors but how nascent cell–cell contacts translate into assembly …
sites with postsynaptic receptors but how nascent cell–cell contacts translate into assembly …
Binary and analog variation of synapses between cortical pyramidal neurons
Learning from experience depends at least in part on changes in neuronal connections. We
present the largest map of connectivity to date between cortical neurons of a defined type …
present the largest map of connectivity to date between cortical neurons of a defined type …