Gene regulatory factors encoded by the nuclear genome are essential for mitochondrial
biogenesis and function. Some of these factors act exclusively within the mitochondria to …

The biogenesis of mitochondria requires the expression of a large number of genes, most of
which reside in the nuclear genome. The protein-coding capacity of mtDNA is limited to 13 …

Eukaryotic transcription factors (TFs) are key determinants of gene activity, yet they bind only
a fraction of their corresponding DNA sequence motifs in any given cell type. Chromatin has …

Fragile X syndrome (FXS) is the most frequent form of inherited intellectual disability and is
also linked to other neurologic and psychiatric disorders. FXS is caused by a triplet …

▪ Abstract Fragile X syndrome is one of the most common forms of inherited mental
retardation. In most cases the disease is caused by the methylation-induced transcriptional …

Our core hypothesis is that the emergence of our species-specific language-ready brain
ought to be understood in light of the developmental changes expressed at the levels of …

Mitochondrial biogenesis (MB) is the essential mechanism by which cells control the number
of mitochondria. Cells respond to different physiologic, metabolic, and pathologic changes …

Upstream stimulating factors (USF), USF‐1 and USF‐2, are members of the eucaryotic
evolutionary conserved basic‐Helix‐Loop‐Helix‐Leucine Zipper transcription factor family …

Friedreich ataxia (FRDA), the most common hereditary ataxia, is caused by mutations in the
frataxin (FXN) gene. The vast majority of FRDA mutations involve expansion of a GAA• TTC …

Abstract Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin with important
functions in neuronal development and neuroplasticity. Accumulating evidence suggests …