This review encompasses the most important advances in liver functions and hepatotoxicity
and analyzes which mechanisms can be studied in vitro. In a complex architecture of nested …

Hepatic fibrosis is a wound healing response to insults and as such affects the entire world
population. In industrialized countries, the main causes of liver fibrosis include alcohol …

Glucose metabolism reprogramming, which is a well‐established characteristic of multiple
cancers, demands a higher rate of glycolysis to meet the increasing demands for …

Over the years, various liver-derived in vitro model systems have been developed to enable
investigation of the potential adverse effects of chemicals and drugs. Liver tissue slices …

Hayes' Principles and Methods of Toxicology has long been established as a reliable and
informative reference for the concepts, methodologies, and assessments integral to …

Precision-cut tissue slices (PCTS) are viable ex vivo explants of tissue with a reproducible,
well defined thickness. They represent a mini-model of the organ under study and contain all …

Primary hepatocytes represent a well-accepted in vitro cell culture system for studies of drug
metabolism, enzyme induction, transplantation, viral hepatitis, and hepatocyte regeneration …

By its anatomical position and biochemical equipment, the liver is involved in the
metabolism and disposition of many foreign substances. While the metabolic transformation …

Precision cut liver slices (PCLSs) retain the structure and cellular composition of the native
liver and represent an improved system to study liver fibrosis compared to two‐dimensional …

The hallmark of liver fibrosis is an increased extracellular matrix deposition, caused by an
activation of hepatic stellate cells (HSC). Therefore, this cell type is an important target for …