Population genomics of bacterial host adaptation

SK Sheppard, DS Guttman, JR Fitzgerald - Nature Reviews Genetics, 2018 - nature.com
Some bacteria can transfer to new host species, and this poses a risk to human health.
Indeed, an estimated 60% of all human pathogens have originated from other animal …

Mechanisms of host adaptation by bacterial pathogens

MF Barber, JR Fitzgerald - FEMS microbiology reviews, 2024 - academic.oup.com
The emergence of new infectious diseases poses a major threat to humans, animals, and
broader ecosystems. Defining factors that govern the ability of pathogens to adapt to new …

Staphylococcus aureus in Animals

AF Haag, JR Fitzgerald, JR Penadés - Microbiology spectrum, 2019 - journals.asm.org
Staphylococcus aureus is a mammalian commensal and opportunistic pathogen that
colonizes niches such as skin, nares and diverse mucosal membranes of about 20-30% of …

Manipulation of innate and adaptive immunity by staphylococcal superantigens

SW Tuffs, SMM Haeryfar, JK McCormick - Pathogens, 2018 - mdpi.com
Staphylococcal superantigens (SAgs) constitute a family of potent exotoxins secreted by
Staphylococcus aureus and other select staphylococcal species. SAgs function to cross-link …

Prophage-encoded immune evasion factors are critical for Staphylococcus aureus host infection, switching, and adaptation

C Chaguza, JT Smith, SA Bruce, R Gibson, IW Martin… - Cell genomics, 2022 - cell.com
Staphylococcus aureus is a multi-host pathogen that causes infections in animals and
humans globally. The specific genetic loci—and the extent to which they drive cross-species …

Into the storm: Chasing the opportunistic pathogen Staphylococcus aureus from skin colonisation to life‐threatening infections

JP O'Gara - Environmental microbiology, 2017 - Wiley Online Library
Colonisation of the human skin by Staphylococcus aureus is a precursor for a variety of
infections ranging from boils to sepsis and pneumonia. The rapid emergence of methicillin …

A novel staphylococcal enterotoxin SE02 involved in a staphylococcal food poisoning outbreak that occurred in Tokyo in 2004

Y Suzuki, HK Ono, Y Shimojima, H Kubota, R Kato… - Food …, 2020 - Elsevier
Staphylococcal enterotoxins (SEs) are extracellular proteins, produced mainly by
Staphylococcus aureus, which cause staphylococcal food poisoning (SFP) when ingested …

Extensive Horizontal Gene Transfer within and between Species of Coagulase-Negative Staphylococcus

JT Smith, CP Andam - Genome biology and evolution, 2021 - academic.oup.com
Members of the gram-positive bacterial genus Staphylococcus have historically been
classified into coagulase-positive Staphylococcus (CoPS) and coagulase-negative …

[HTML][HTML] Superantigens, a paradox of the immune response

S Noli Truant, DM Redolfi, MB Sarratea, EL Malchiodi… - Toxins, 2022 - mdpi.com
Staphylococcal enterotoxins are a wide family of bacterial exotoxins with the capacity to
activate as much as 20% of the host T cells, which is why they were called superantigens …

Genomic epidemiology of methicillin-resistant and -susceptible Staphylococcus aureus from bloodstream infections

JT Smith, EM Eckhardt, NB Hansel, TR Eliato… - BMC infectious …, 2021 - Springer
Background Bloodstream infections due to Staphylococcus aureus cause significant patient
morbidity and mortality worldwide. Of major concern is the emergence and spread of …