Models of cardiac tissue electrophysiology are an important component of the Cardiac
Physiome Project, which is an international effort to build biophysically based multi-scale …

The heart automaticity is a fundamental physiological function in higher organisms. The
spontaneous activity is initiated by specialized populations of cardiac cells generating …

Background: Left bundle branch pacing (LBBP) is a novel pacing method and has been
observed to have low and stable pacing thresholds in prior small short-term studies. The …

Despite the significant decline in coronary artery disease (CAD) mortality in the second half
of the 20th century, 1 sudden cardiac death (SCD) continues to claim 250 000 to 300 000 …

The heartbeat originates within the sinoatrial node (SAN), a small structure containing<
10,000 genuine pacemaker cells. If the SAN fails, the∼ 5 billion working cardiomyocytes …

Background—Although we know much about the molecular makeup of the sinus node (SN)
in small mammals, little is known about it in humans. The aims of the present study were to …

artery (Figure 2B), although the relationship to the artery varies from individual to individual.
8 The nodal cells are set in a matrix of fibrous tissue, with a relatively discrete boundary …

Diabetes increases oxidant stress and doubles the risk of dying after myocardial infarction,
but the mechanisms underlying increased mortality are unknown. Mice with streptozotocin …

Sinus node dysfunction (SND) is a major public health problem that is associated with
sudden cardiac death and requires surgical implantation of artificial pacemakers. However …

It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …