Every year, cancer claims millions of lives around the globe. Unfortunately, model systems
that accurately mimic human oncology–a requirement for the development of more effective …

Despite advances in medicine and biomedical sciences, cancer still remains a major health
issue. Complex interactions between tumors and their microenvironment contribute to tumor …

The hedgehog (Hh) pathway is a sophisticated conserved cell signaling pathway that plays
an essential role in controlling cell specification and proliferation, survival factors, and tissue …

The transition to increasingly sophisticated microfluidic systems has led to the emergence of
“organ-on-chip” technology that can faithfully recapitulate organ-level function. Given the …

More than two decades ago, microfluidics began to show its impact in biological research.
Since then, the field of microfluidics has evolving rapidly. Cancer is one of the leading …

Hedgehog (HH) and TGF-β signals control various aspects of embryonic development and
cancer progression. While their canonical signal transduction cascades have been well …

The microbial secondary metabolome encompasses great synthetic diversity, empowering
microbes to tune their chemical responses to changing microenvironments. Traditional …

Background: Metastatic outgrowth in breast cancer can occur years after a seeming cure.
Existing model systems of dormancy are limited as they do not recapitulate human …

The concept of “Organs-on-Chips” has recently evolved and has been described as 3D (mini-
) organs or tissues consisting of multiple and different cell types interacting with each other …

The inadequacy of effective treatment approaches for prostate cancer enlightens the crucial
necessity for the search and emergence of novel and multitasking anticancer substances …