Neuronal circuitry for recognition memory of object and place in rodent models

OY Chao, S Nikolaus, YM Yang, JP Huston - … & Biobehavioral Reviews, 2022 - Elsevier
Rats and mice are used for studying neuronal circuits underlying recognition memory due to
their ability to spontaneously remember the occurrence of an object, its place and an …

Neuronal vector coding in spatial cognition

A Bicanski, N Burgess - Nature Reviews Neuroscience, 2020 - nature.com
Several types of neurons involved in spatial navigation and memory encode the distance
and direction (that is, the vector) between an agent and items in its environment. Such …

Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer's disease

Q Sun, J Zhang, A Li, M Yao, G Liu, S Chen… - Nature …, 2022 - nature.com
Short-term memory deficits have been associated with prefrontal cortex (PFC) dysfunction in
Alzheimer's disease (AD) and AD mouse models. Extratelencephalic projection (ET) …

Subicular neurons encode concave and convex geometries

Y Sun, DA Nitz, X Xu, LM Giocomo - Nature, 2024 - nature.com
Animals in the natural world constantly encounter geometrically complex landscapes.
Successful navigation requires that they understand geometric features of these landscapes …

[HTML][HTML] Predictive maps in rats and humans for spatial navigation

W De Cothi, N Nyberg, EM Griesbauer, C Ghanamé… - Current Biology, 2022 - cell.com
Much of our understanding of navigation comes from the study of individual species, often
with specific tasks tailored to those species. Here, we provide a novel experimental and …

Viral vectors for neural circuit map** and recent advances in trans-synaptic anterograde tracers

X Xu, TC Holmes, MH Luo, KT Beier, GD Horwitz… - Neuron, 2020 - cell.com
Viral tracers are important tools for neuroanatomical map** and genetic payload delivery.
Genetically modified viruses allow for cell-type-specific targeting and overcome many …

Probing neural circuit mechanisms in Alzheimer's disease using novel technologies

SF Grieco, TC Holmes, X Xu - Molecular Psychiatry, 2023 - nature.com
The study of Alzheimer's Disease (AD) has traditionally focused on neuropathological
mechanisms that has guided therapies that attenuate neuropathological features. A new …

Propagation of hippocampal ripples to the neocortex by way of a subiculum-retrosplenial pathway

N Nitzan, S McKenzie, P Beed, DF English… - Nature …, 2020 - nature.com
Bouts of high frequency activity known as sharp wave ripples (SPW-Rs) facilitate
communication between the hippocampus and neocortex. However, the paths and …

Olfactory bulb activity shapes the development of entorhinal-hippocampal coupling and associated cognitive abilities

YN Chen, JK Kostka, SH Bitzenhofer… - Current Biology, 2023 - cell.com
The interplay between olfaction and higher cognitive processing has been documented in
the adult brain; however, its development is poorly understood. In mice, shortly after birth …

[HTML][HTML] Characteristics of fMRI responses to visual stimulation in anesthetized vs. awake mice

TNA Dinh, WB Jung, HJ Shim, SG Kim - Neuroimage, 2021 - Elsevier
The functional characteristics of the mouse visual system have not previously been well
explored using fMRI. In this research, we examined 9.4 T BOLD fMRI responses to visual …