Protein misfolding and aggregation in cataract disease and prospects for prevention
The transparency of the eye lens depends on maintaining the native tertiary structures and
solubility of the lens crystallin proteins over a lifetime. Cataract, the leading cause of …
solubility of the lens crystallin proteins over a lifetime. Cataract, the leading cause of …
Ocular delivery of proteins and peptides: Challenges and novel formulation approaches
The impact of proteins and peptides on the treatment of various conditions including ocular
diseases over the past few decades has been advanced by substantial breakthroughs in …
diseases over the past few decades has been advanced by substantial breakthroughs in …
Overcoming the crystallization and designability issues in the ultrastable zirconium phosphonate framework system
Metal-organic frameworks (MOFs) based on zirconium phosphonates exhibit superior
chemical stability suitable for applications under harsh conditions. These compounds mostly …
chemical stability suitable for applications under harsh conditions. These compounds mostly …
Stimuli-responsive, pentapeptide, nanofiber hydrogel for tissue engineering
Short peptides are uniquely versatile building blocks for self-assembly. Supramolecular
peptide assemblies can be used to construct functional hydrogel biomaterials—an attractive …
peptide assemblies can be used to construct functional hydrogel biomaterials—an attractive …
Weak interactions govern the viscosity of concentrated antibody solutions: high-throughput analysis using the diffusion interaction parameter
Weak protein-protein interactions are thought to modulate the viscoelastic properties of
concentrated antibody solutions. Predicting the viscoelastic behavior of concentrated …
concentrated antibody solutions. Predicting the viscoelastic behavior of concentrated …
Biophysics of protein evolution and evolutionary protein biophysics
The study of molecular evolution at the level of protein-coding genes often entails comparing
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
large datasets of sequences to infer their evolutionary relationships. Despite the importance …
Cataract
Cataract is the leading cause of reversible blindness and visual impairment globally.
Blindness from cataract is more common in populations with low socioeconomic status and …
Blindness from cataract is more common in populations with low socioeconomic status and …
Protein corona mitigates the cytotoxicity of graphene oxide by reducing its physical interaction with cell membrane
Many recent studies have shown that the way nanoparticles interact with cells and biological
molecules can vary greatly in the serum-containing or serum-free culture medium. However …
molecules can vary greatly in the serum-containing or serum-free culture medium. However …
Graphene-induced pore formation on cell membranes
Examining interactions between nanomaterials and cell membranes can expose underlying
mechanisms of nanomaterial cytotoxicity and guide the design of safer nanomedical …
mechanisms of nanomaterial cytotoxicity and guide the design of safer nanomedical …
PKM2 aggregation drives metabolism reprograming during aging process
While protein aggregation's association with aging and age-related diseases is well-
established, the specific proteins involved and whether dissolving them could alleviate …
established, the specific proteins involved and whether dissolving them could alleviate …