Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

The NLRP3 inflammasome is a cytosolic multiprotein complex composed of the innate
immune receptor protein NLRP3, adapter protein ASC, and inflammatory protease caspase …

Optimum protein function and biochemical activity critically depends on water availability
because solvent thermodynamics drive protein folding and macromolecular interactions …

Macromolecular crowding affects the activity of proteins and functional macromolecular
complexes in all cells, including bacteria. Crowding, together with physicochemical …

The intracellular coral–dinoflagellate symbiosis is the engine that underpins the success of
coral reefs, one of the most diverse ecosystems on the planet. However, the breakdown of …

Intracellular delivery is a key step in biological research and has enabled decades of
biomedical discoveries. It is also becoming increasingly important in industrial and medical …

During osmotic changes of their environment, cells actively regulate their volume and
plasma membrane tension that can passively change through osmosis. How tension and …

Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect
cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase …

Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they
can die through programmed cell death upon the stimulation of specific signalling pathways …

The enzyme cyclic GMP-AMP synthase (cGAS) senses cytosolic DNA in infected and
malignant cells and catalyzes the formation of 2′ 3′ cGMP-AMP (cGAMP), which in turn …