Amide bond formation: beyond the myth of coupling reagents

E Valeur, M Bradley - Chemical Society Reviews, 2009 - pubs.rsc.org
Amide bond formation is a fundamentally important reaction in organic synthesis, and is
typically mediated by one of a myriad of so-called coupling reagents. This critical review is …

Acyl Fluorides in Late‐Transition‐Metal Catalysis

Y Ogiwara, N Sakai - Angewandte Chemie International Edition, 2020 - Wiley Online Library
In this Review, we summarize the current state of the art in late‐transition‐metal‐catalyzed
reactions of acyl fluorides, covering both their synthesis and further transformations. In …

Carboxylic acid deoxyfluorination and one-pot amide bond formation using pentafluoropyridine (PFP)

WDG Brittain, SL Cobb - Organic Letters, 2021 - ACS Publications
This work describes the application of pentafluoropyridine (PFP), a cheap commercially
available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl …

The growing synthetic utility of the Weinreb amide

S Balasubramaniam, IS Aidhen - Synthesis, 2008 - thieme-connect.com
Abstract N-Methoxy-N-methylamide, popularly addressed as the Weinreb amide, has
surfaced as an amide with a difference. This amide has served as an excellent acylating …

Direct Synthesis of Acyl Fluorides from Carboxylic Acids with the Bench-Stable Solid Reagent (Me4N)SCF3

T Scattolin, K Deckers, F Schoenebeck - Organic letters, 2017 - ACS Publications
A convenient, highly efficient, and selective transformation of aliphatic and aromatic
carboxylic acids to acyl fluorides is reported. In contrast to established approaches that …

A protocol for amide bond formation with electron deficient amines and sterically hindered substrates

ME Due-Hansen, SK Pandey, E Christiansen… - Organic & …, 2016 - pubs.rsc.org
A protocol for amide bond formation with electron deficient amines and sterically hindered
substrates - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C5OB02129D …

Synthesis of acyl fluorides via photocatalytic fluorination of aldehydic C–H bonds

M Meanwell, J Lehmann, M Eichenberger… - Chemical …, 2018 - pubs.rsc.org
Acyl fluorides are versatile acylating agents owing to their unique stability. Their synthesis,
however, can present challenges and is typically accomplished through deoxyfluorination of …

Clickable coupling of carboxylic acids and amines at room temperature mediated by SO 2 F 2: a significant breakthrough for the construction of amides and peptide …

SM Wang, C Zhao, X Zhang, HL Qin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The construction of amide bonds and peptide linkages is one of the most fundamental
transformations in all life processes and organic synthesis. The synthesis of structurally …

Deoxyfluorination of carboxylic acids with CpFluor: access to acyl fluorides and amides

X Wang, F Wang, F Huang, C Ni, J Hu - Organic Letters, 2021 - ACS Publications
3, 3-Difluoro-1, 2-diphenylcyclopropene (CpFluor), a bench-stable fluorination reagent, has
been developed in the deoxyfluorination of carboxylic acids to afford various acyl fluorides …

Nickel-catalysed decarbonylative borylation of aroyl fluorides

Z Wang, X Wang, Y Nishihara - Chemical Communications, 2018 - pubs.rsc.org
The first Ni (cod) 2/PPh3 catalyst system has been established for decarbonylative
borylation of aroyl fluorides with bis (pinacolato) diboron. A wide range of functional groups …