Amide bond formation: beyond the myth of coupling reagents
E Valeur, M Bradley - Chemical Society Reviews, 2009 - pubs.rsc.org
Amide bond formation is a fundamentally important reaction in organic synthesis, and is
typically mediated by one of a myriad of so-called coupling reagents. This critical review is …
typically mediated by one of a myriad of so-called coupling reagents. This critical review is …
Acyl Fluorides in Late‐Transition‐Metal Catalysis
Y Ogiwara, N Sakai - Angewandte Chemie International Edition, 2020 - Wiley Online Library
In this Review, we summarize the current state of the art in late‐transition‐metal‐catalyzed
reactions of acyl fluorides, covering both their synthesis and further transformations. In …
reactions of acyl fluorides, covering both their synthesis and further transformations. In …
Carboxylic acid deoxyfluorination and one-pot amide bond formation using pentafluoropyridine (PFP)
This work describes the application of pentafluoropyridine (PFP), a cheap commercially
available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl …
available reagent, in the deoxyfluorination of carboxylic acids to acyl fluorides. The acyl …
The growing synthetic utility of the Weinreb amide
S Balasubramaniam, IS Aidhen - Synthesis, 2008 - thieme-connect.com
Abstract N-Methoxy-N-methylamide, popularly addressed as the Weinreb amide, has
surfaced as an amide with a difference. This amide has served as an excellent acylating …
surfaced as an amide with a difference. This amide has served as an excellent acylating …
Direct Synthesis of Acyl Fluorides from Carboxylic Acids with the Bench-Stable Solid Reagent (Me4N)SCF3
A convenient, highly efficient, and selective transformation of aliphatic and aromatic
carboxylic acids to acyl fluorides is reported. In contrast to established approaches that …
carboxylic acids to acyl fluorides is reported. In contrast to established approaches that …
A protocol for amide bond formation with electron deficient amines and sterically hindered substrates
ME Due-Hansen, SK Pandey, E Christiansen… - Organic & …, 2016 - pubs.rsc.org
A protocol for amide bond formation with electron deficient amines and sterically hindered
substrates - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C5OB02129D …
substrates - Organic & Biomolecular Chemistry (RSC Publishing) DOI:10.1039/C5OB02129D …
Synthesis of acyl fluorides via photocatalytic fluorination of aldehydic C–H bonds
Acyl fluorides are versatile acylating agents owing to their unique stability. Their synthesis,
however, can present challenges and is typically accomplished through deoxyfluorination of …
however, can present challenges and is typically accomplished through deoxyfluorination of …
Clickable coupling of carboxylic acids and amines at room temperature mediated by SO 2 F 2: a significant breakthrough for the construction of amides and peptide …
SM Wang, C Zhao, X Zhang, HL Qin - Organic & Biomolecular …, 2019 - pubs.rsc.org
The construction of amide bonds and peptide linkages is one of the most fundamental
transformations in all life processes and organic synthesis. The synthesis of structurally …
transformations in all life processes and organic synthesis. The synthesis of structurally …
Deoxyfluorination of carboxylic acids with CpFluor: access to acyl fluorides and amides
X Wang, F Wang, F Huang, C Ni, J Hu - Organic Letters, 2021 - ACS Publications
3, 3-Difluoro-1, 2-diphenylcyclopropene (CpFluor), a bench-stable fluorination reagent, has
been developed in the deoxyfluorination of carboxylic acids to afford various acyl fluorides …
been developed in the deoxyfluorination of carboxylic acids to afford various acyl fluorides …
Nickel-catalysed decarbonylative borylation of aroyl fluorides
Z Wang, X Wang, Y Nishihara - Chemical Communications, 2018 - pubs.rsc.org
The first Ni (cod) 2/PPh3 catalyst system has been established for decarbonylative
borylation of aroyl fluorides with bis (pinacolato) diboron. A wide range of functional groups …
borylation of aroyl fluorides with bis (pinacolato) diboron. A wide range of functional groups …