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Phenotypes and endotypes of adult asthma: moving toward precision medicine
Asthma is a chronic inflammatory disease of the airways that is challenging to dissect into
subgroups because of the heterogeneity present across the spectrum of the disease. Efforts …
subgroups because of the heterogeneity present across the spectrum of the disease. Efforts …
Asthma phenotypes: the evolution from clinical to molecular approaches
Although asthma has been considered as a single disease for years, recent studies have
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …
increasingly focused on its heterogeneity. The characterization of this heterogeneity has …
Asthma endotypes and an overview of targeted therapy for asthma
Guidelines for the management of severe asthma do not emphasize the measurement of the
inflammatory component of airway disease to indicate appropriate treatments or to monitor …
inflammatory component of airway disease to indicate appropriate treatments or to monitor …
How inhaled corticosteroids target inflammation in COPD
Inhaled corticosteroids (ICS) are the most commonly used anti-inflammatory drugs for the
treatment of COPD. COPD has been previously described as a “corticosteroid-resistant” …
treatment of COPD. COPD has been previously described as a “corticosteroid-resistant” …
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials …
Background: The assessment of asthma control is pivotal to the evaluation of treatment
response in individuals and in clinical trials. Previously, asthma control, severity, and …
response in individuals and in clinical trials. Previously, asthma control, severity, and …
Inflammatory subtypes in asthma: assessment and identification using induced sputum
Objective: The authors sought to investigate the detection of non‐eosinophilic asthma using
induced sputum. Although this is an important subtype of clinical asthma, its recognition is …
induced sputum. Although this is an important subtype of clinical asthma, its recognition is …
A large subgroup of mild-to-moderate asthma is persistently noneosinophilic
KW McGrath, N Icitovic, HA Boushey… - American journal of …, 2012 - atsjournals.org
Rationale: Airway eosinophilia is typical of asthma, and many controller treatments target
eosinophilic disease. Asthma is clinically heterogeneous, however, and a subgroup of …
eosinophilic disease. Asthma is clinically heterogeneous, however, and a subgroup of …
Analysis of induced sputum in adults with asthma: identification of subgroup with isolated sputum neutrophilia and poor response to inhaled corticosteroids
Background: The debate as to whether asthma is a single or heterogeneous disease
remains unresolved although pathological studies, mostly using fibreoptic bronchoscopy on …
remains unresolved although pathological studies, mostly using fibreoptic bronchoscopy on …
Asthma endoty** and biomarkers in childhood asthma
Childhood asthma represents a heterogeneous challenging disease, in particular in its
severe forms. The identification of different asthma phenotypes has stimulated research in …
severe forms. The identification of different asthma phenotypes has stimulated research in …
Asthma outcomes: biomarkers
BACKGROUND: Measurement of biomarkers has been incorporated within clinical research
studies of asthma to characterize the population and associate the disease with …
studies of asthma to characterize the population and associate the disease with …