Pulmonary inhalation administration is an ideal approach to locally treat lung disease and to
achieve systemic administration for other diseases. However, the complex nature of the …

This review examines the effects of particle properties on drug–carrier interactions in the
preparation of a dry powder inhaler (DPI) formulation, including appropriate mixing …

Pulmonary drug delivery has gained great attention in local or systemic diseases therapy,
however it is still difficult to scale-up DPI production due to the complexity of interactions …

Drug delivery from a capsule-based dry powder inhaler depends on the inhaler's design, the
drug's formulation, and the inhalation maneuver. The latter affects both the air flow and the …

Previous studies have shown that combining colistin (Col), a cationic polypeptide antibiotic,
with ivacaftor (Iva), a cystic fibrosis (CF) drug, could achieve synergistic antibacterial effects …

A new theory for the dispersibility enhancing effect of excipient fines for adhesive mixtures
for inhalation is presented in this paper, while at the same time the shortcomings of current …

The potential of fine excipient materials to improve the aerodynamic performance of carrier-
based dry powder inhalation (DPI) formulations is well acknowledged but not fully …

To effectively achieve the pulmonary delivery for curcumin (CN), novel inhalable mucus-
penetrating nanocrystal-based microparticles (INMP) were designed. The D-Tocopherol …

Objectives For dry powder inhalers, the airflow properties in the airways could affect the
deposition of inhaled particles; the flow patterns vary inherently between patients. This …

Introduction: Inhaled drugs are important in the treatment of many lung pathologies, but to be
therapeutically effective they must reach unbound concentrations at their effect site in the …