Long non-coding RNAs and complex diseases: from experimental results to computational models

X Chen, CC Yan, X Zhang, ZH You - Briefings in bioinformatics, 2017 - academic.oup.com
LncRNAs have attracted lots of attentions from researchers worldwide in recent decades.
With the rapid advances in both experimental technology and computational prediction …

Human long noncoding RNA interactome: detection, characterization and function

M Kazimierczyk, MK Kasprowicz, ME Kasprzyk… - International journal of …, 2020 - mdpi.com
The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

The long noncoding RNA MdLNC499 bridges MdWRKY1 and MdERF109 function to regulate early-stage light-induced anthocyanin accumulation in apple fruit

H Ma, T Yang, Y Li, J Zhang, T Wu, T Song… - The Plant …, 2021 - academic.oup.com
Anthocyanin pigments contribute to plant coloration and are valuable sources of
antioxidants in the human diet as components of fruits and vegetables. Their production is …

lncRNAfunc: a knowledgebase of lncRNA function in human cancer

M Yang, H Lu, J Liu, S Wu, P Kim… - Nucleic acids research, 2022 - academic.oup.com
The long non-coding RNAs associating with other molecules can coordinate several
physiological processes and their dysfunction can impact diverse human diseases. To date …

LncRNA MIR200CHG inhibits EMT in gastric cancer by stabilizing miR-200c from target-directed miRNA degradation

Y Zhu, C Huang, C Zhang, Y Zhou, E Zhao… - Nature …, 2023 - nature.com
Gastric cancer (GC) is a heterogeneous disease, threatening millions of lives worldwide, yet
the functional roles of long non-coding RNAs (lncRNAs) in different GC subtypes remain …

LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling

H Liu, H Deng, Y Zhao, C Li, Y Liang - Journal of Experimental & Clinical …, 2018 - Springer
Background Thyroid cancer is one of the most prevalent malignancies in endocrine system.
Further understanding and revealing the molecular mechanism underlying thyroid cancer …

Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung …

K Yang, W Zhang, L Zhong, Y **ao, S Sahoo… - Cell Death & …, 2023 - nature.com
Lung cancer is the leading cause of cancer-related deaths worldwide. KRAS is the main
oncogenic driver in lung cancer that can be activated by gene mutation or amplification, but …

A novel mechanism of lncRNA and miRNA interaction: CCAT2 regulates miR-145 expression by suppressing its maturation process in colon cancer cells

Y Yu, P Nangia-Makker, L Farhana, APN Majumdar - Molecular cancer, 2017 - Springer
Background Although both long and micro RNAs are emerging as important functional
components in colorectal cancer (CRC) progression and metastasis, the mechanism of their …

GKLOMLI: a link prediction model for inferring miRNA–lncRNA interactions by using Gaussian kernel-based method on network profile and linear optimization …

L Wong, L Wang, ZH You, CA Yuan, YA Huang… - BMC …, 2023 - Springer
Background The limited knowledge of miRNA–lncRNA interactions is considered as an
obstruction of revealing the regulatory mechanism. Accumulating evidence on Human …

A novel long non-coding RNA CYP4B1-PS1-001 regulates proliferation and fibrosis in diabetic nephropathy

M Wang, S Wang, D Yao, Q Yan, W Lu - Molecular and cellular …, 2016 - Elsevier
Diabetic nephropathy is an important microvascular complication of diabetes, and the
incidence of end-stage renal disease caused by it are rising annually. Long non-coding …