Prostate Cancer Biomarkers: From diagnosis to prognosis and precision-guided therapeutics

M Adamaki, V Zoumpourlis - Pharmacology & therapeutics, 2021 - Elsevier
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and among the
leading causes of cancer-related death worldwide. It is a highly heterogeneous disease …

The fat side of prostate cancer

G Zadra, C Photopoulos, M Loda - … et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Prostate cancer (PCa) metabolism appears to be unique in comparison with other types of
solid cancers. Normal prostate cells mainly rely on glucose oxidation to provide precursors …

Current status of biomarkers for prostate cancer

VM Velonas, HH Woo, CG dos Remedios… - International journal of …, 2013 - mdpi.com
Prostate cancer (PCa) is a leading cause of cancer-related death of men globally. Since its
introduction, there has been intense debate as to the effectiveness of the prostate specific …

Caveolin‐1, cancer and therapy resistance

J Ketteler, D Klein - International journal of cancer, 2018 - Wiley Online Library
Resistance of solid tumors to chemo‐and radiotherapy remains a major obstacle in anti‐
cancer treatment. Herein, the membrane protein caveolin‐1 (CAV1) came into focus as it is …

Extracellular vesicles for liquid biopsy in prostate cancer: where are we and where are we headed?

VR Minciacchi, A Zijlstra, MA Rubin… - Prostate cancer and …, 2017 - nature.com
Background: Extracellular vesicles (EVs) are a heterogeneous class of lipid bound particles
shed by any cell in the body in physiological and pathological conditions. EVs play critical …

p53 as a regulator of lipid metabolism in cancer

A Parrales, T Iwakuma - International journal of molecular sciences, 2016 - mdpi.com
Enhanced proliferation and survival are common features of cancer cells. Cancer cells are
metabolically reprogrammed which aids in their survival in nutrient-poor environments …

Loss of caveolin‐1 in prostate cancer stroma correlates with reduced relapse‐free survival and is functionally relevant to tumour progression

G Ayala, M Morello, A Frolov, S You, R Li… - The Journal of …, 2013 - Wiley Online Library
Abstract Levels of caveolin‐1 (Cav‐1) in tumour epithelial cells increase during prostate
cancer progression. Conversely, Cav‐1 expression in the stroma can decline in advanced …

Comprehensive palmitoyl-proteomic analysis identifies distinct protein signatures for large and small cancer-derived extracellular vesicles

J Mariscal, T Vagner, M Kim, B Zhou… - Journal of …, 2020 - Taylor & Francis
Extracellular vesicles (EVs) are membrane-enclosed particles that play an important role in
cancer progression and have emerged as a promising source of circulating biomarkers …

Gravity‐sensitive signaling drives 3‐dimensional formation of multicellular thyroid cancer spheroids

J Grosse, M Wehland, J Pietsch, H Schulz… - The FASEB …, 2012 - Wiley Online Library
This study focused on the effects induced by a random positioning machine (RPM) on FTC‐
133 thyroid cancer cells and evaluated signaling elements involved in 3‐dimensional …

[HTML][HTML] High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers

K Grupp, S Sanader, H Sirma, R Simon, C Koop… - Molecular …, 2013 - Elsevier
Abstract Lysophosphatidylcholine acyltransferase 1 (LPCAT1) has been suggested to play a
role in cancer. To assess its role in prostate cancer, LPCAT1 expression was analyzed on a …