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Nano biomaterials based strategies for enhanced brain targeting in the treatment of neurodegenerative diseases: An up-to-date perspective
Neurons and their connecting axons gradually degenerate in neurodegenerative diseases
(NDs), leading to dysfunctionality of the neuronal cells and eventually their death. Drug …
(NDs), leading to dysfunctionality of the neuronal cells and eventually their death. Drug …
[HTML][HTML] Intranasal polymeric and lipid-based nanocarriers for CNS drug delivery
Nanomedicine is currently focused on the design and development of nanocarriers that
enhance drug delivery to the brain to address unmet clinical needs for treating …
enhance drug delivery to the brain to address unmet clinical needs for treating …
Injectable dual thermoreversible hydrogel for sustained intramuscular drug delivery
Herein, we reported novel docetaxel-decorated solid lipid nanoparticle (DCT-SLN)-loaded
dual thermoreversible system (DCT-DRTS) for intramuscular administration with reduced …
dual thermoreversible system (DCT-DRTS) for intramuscular administration with reduced …
Preparation, characterization, and pharmacological application of oral Honokiol-loaded solid lipid nanoparticles for diabetic neuropathy
Honokiol is a phytochemical component with a variety of pharmacological properties.
However, the major limitation of Honokiol is its poor solubility and low oral bioavailability. In …
However, the major limitation of Honokiol is its poor solubility and low oral bioavailability. In …
Quality by design for sumatriptan loaded nano-ethosomal mucoadhesive gel for the therapeutic management of nitroglycerin induced migraine
Migraine is a progressive neurological condition often accompanied by nausea and
vomiting. Various drugs have recently been used in the treatment of migraine, including …
vomiting. Various drugs have recently been used in the treatment of migraine, including …
Development, Characterization, and Evaluation of SLN‐Loaded Thermoresponsive Hydrogel System of Topotecan as Biological Macromolecule for Colorectal …
Background. Chemotherapeutic drugs cause severe toxicities if administered unprotected,
without proper targeting, and controlled release. In this study, we developed topotecan‐(TPT …
without proper targeting, and controlled release. In this study, we developed topotecan‐(TPT …
[HTML][HTML] Potential and applications of nanocarriers for efficient delivery of biopharmaceuticals
During the past two decades, the clinical use of biopharmaceutical products has markedly
increased because of their obvious advantages over conventional small-molecule drug …
increased because of their obvious advantages over conventional small-molecule drug …
[HTML][HTML] Solubilization techniques used for poorly water-soluble drugs
Currently, about 40% of approved drugs and nearly 90% of drug candidates are poorly
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …
water-soluble drugs. Low solubility reduces the likelihood that these drugs can be effectively …
Nose to brain delivery of escitalopram-loaded nano-structured lipid carriers thermosensitive gel: Formulation, physiochemical, pharmacokinetic and …
The primary focus of the undertaken research was to design and develop poloxamer-based
thermosensitive gel system of escitalopram-loaded nano-structured lipid carriers (ESC …
thermosensitive gel system of escitalopram-loaded nano-structured lipid carriers (ESC …
Enhanced neuroprotective and antidepressant activity of curcumin-loaded nanostructured lipid carriers in lipopolysaccharide-induced depression and anxiety rat …
The present study aims to develop curcumin-loaded nanostructured lipid carriers (CUR-
NLCs) and investigate their neuroprotective effects in lipopolysaccharide (LPS)-induced …
NLCs) and investigate their neuroprotective effects in lipopolysaccharide (LPS)-induced …