Src family kinases (SFKs) are non-receptor kinases that play a critical role in the
pathogenesis of colorectal cancer (CRC). The expression and activity of SFKs are …

Crk and CrkL are cellular counterparts of the viral oncoprotein v-Crk. Crk and CrkL are
overexpressed in many types of human cancer, correlating with poor prognosis …

Colon cancer is the fourth leading cause of cancer death worldwide, and its progression is
accompanied by a complex array of genetic variations. CRISPR/Cas9 can identify new drug …

Intracellular adaptor proteins are indispensable for the transduction of receptor‐derived
signals, as they recruit and connect essential downstream effectors. The SLy/SASH1 …

Background The serious side effect of current conventional treatments for patients with
metastatic colorectal cancer (CRC) highlights the requirement of an alternative treatment …

Triple-negative breast cancer (TNBC) is extremely aggressive and lacks effective therapy.
SAM and SH3 domain containing1 (SASH1) has been implicated in TNBC as a candidate …

Simple Summary Cancer is a leading cause of death worldwide, with most of these deaths
being the result of tumor metastasis (spread of cancer cells from the primary site). The sterile …

The Eph (erythropoietin-producing human hepatocellular) receptor family, the largest
subclass of receptor tyrosine kinases (RTKs), plays essential roles in embryonic …

Simple Summary Triple-negative breast cancer (TNBC) has a high recurrence rate and
metastasis rate, and the prognosis for patients is poor. Identifying novel treatment avenues …

Epithelial–mesenchymal transition (EMT) is a cell plasticity process required for metastasis
and chemoresistance of carcinoma cells. We report a crucial role of the signal adaptor …