Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Conventional cancer therapies suffer from severe off-target effects because most of them
target critical facets of cells that are generally shared by all rapidly proliferating cells. The …

Metal–organic frameworks (MOFs) are a class of important porous, crystalline materials
composed of metal ions (clusters) and organic ligands. Owing to the unique redox chemistry …

Disulfiram (DSF) has been used as an alcoholism drug for 70 years. Recently, it has
attracted increasing attention owing to the distinguished anticancer activity, which can be …

Reactive oxygen species (ROS) play a crucial role in physiological and pathological
processes, emerging as a therapeutic target in cancer. Owing to the high concentration of …

Epigallocatechin gallate (EGCG)-based nanosystems have garnered significant attention for
their ability to alleviate inflammation due to their excellent anti-inflammatory properties and …

Disulfiram (DSF) is a thiocarbamate based drug that has been approved for treating
alcoholism for over 60 years. Preclinical studies have shown that DSF has anticancer …

The way that cancer cells die inspires treatment regimens and cytolytic cuproptosis induced
by copper complexes, like copper (II) bis (diethyldithiocarbamate)(CuET), has emerged as a …

Therapeutic nanosystems triggered by a specific tumor microenvironment (TME) offer
excellent safety and selectivity in the treatment of cancer by in situ conversion of a less toxic …