Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Sex differences in blood pressure regulation and hypertension: renal, hemodynamic, and hormonal mechanisms
The teleology of sex differences has been argued since at least as early as Aristotle's
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …
controversial Generation of Animals more than 300 years BC, which reflects the sex bias of …
Potential role of CYP1B1 in the development and treatment of metabolic diseases
Abstract Cytochrome P450 1B1 (CYP1B1), a member of CYP superfamily, is expressed in
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …
liver and extrahepatic tissues carries out the metabolism of numerous xenobiotics, including …
Intestinal microbiota by angiotensin receptor blocker therapy exerts protective effects against hypertensive damages
J Li, SY Wang, KX Yan, P Wang, J Jiao, YD Wang… - Imeta, 2024 - Wiley Online Library
Dysbiosis of the gut microbiota has been implicated in hypertension, and drug–host–
microbiome interactions have drawn considerable attention. However, the influence of …
microbiome interactions have drawn considerable attention. However, the influence of …
Single nuclei sequencing reveals novel insights into the regulation of cellular signatures in children with dilated cardiomyopathy
Background: Dilated cardiomyopathy (DCM) is a leading cause of death in children with
heart failure. The outcome of pediatric heart failure treatment is inconsistent, and large …
heart failure. The outcome of pediatric heart failure treatment is inconsistent, and large …
Inhibition of heme-thiolate monooxygenase CYP1B1 prevents hepatic stellate cell activation and liver fibrosis by accumulating trehalose
Activation of extracellular matrix–producing hepatic stellate cells (HSCs) is a key event in
liver fibrogenesis. We showed that the expression of the heme-thiolate monooxygenase …
liver fibrogenesis. We showed that the expression of the heme-thiolate monooxygenase …
[HTML][HTML] Uncovering sex-specific mechanisms of action of testosterone and redox balance
D Cruz-Topete, P Dominic, KY Stokes - Redox Biology, 2020 - Elsevier
The molecular and pharmacological manipulation of the endogenous redox system is a
promising therapy to limit myocardial damage after a heart attack; however, antioxidant …
promising therapy to limit myocardial damage after a heart attack; however, antioxidant …
Isorhamnetin: a novel natural product beneficial for cardiovascular disease
WQ Li, J Li, WX Liu, LJ Wu, JY Qin… - Current …, 2022 - ingentaconnect.com
Cardiovascular disease (CVD) has become a severe threat to human beings with increasing
morbidity and mortality. Isorhamnetin (Iso) shows multiple bioactivities, especially in the …
morbidity and mortality. Isorhamnetin (Iso) shows multiple bioactivities, especially in the …
Reactive oxygen species: players in the cardiovascular effects of testosterone
Androgens are essential for the development and maintenance of male reproductive tissues
and sexual function and for overall health and well being. Testosterone, the predominant …
and sexual function and for overall health and well being. Testosterone, the predominant …
Cytochrome P450 1B1: A key regulator of ocular iron homeostasis and oxidative stress
Cytochrome P450 (CYP) 1B1 belongs to the superfamily of heme-containing
monooxygenases. Unlike other CYP enzymes, which are highly expressed in the liver …
monooxygenases. Unlike other CYP enzymes, which are highly expressed in the liver …