The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis

BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …

Hematological toxicities associated with linezolid therapy in adults: key findings and clinical considerations

D Cattaneo, DJE Marriott… - Expert Review of Clinical …, 2023 - Taylor & Francis
Introduction Linezolid can cause serious adverse effects including thrombocytopenia and
anemia. Here, we focus specifically on linezolid-related hematological toxicity in adult …

Nanosized Drug Delivery Systems to Fight Tuberculosis

T Bourguignon, JA Godinez-Leon, R Gref - Pharmaceutics, 2023 - mdpi.com
Tuberculosis (TB) is currently the second deadliest infectious disease. Existing
antitubercular therapies are long, complex, and have severe side effects that result in low …

Implementation of bedaquiline, pretomanid, and linezolid in the United States: experience using a novel all-oral treatment regimen for treatment of rifampin-resistant or …

CA Haley, MC Schechter, D Ashkin… - Clinical Infectious …, 2023 - academic.oup.com
Background Rifampin-resistant tuberculosis is a leading cause of morbidity worldwide; only
one-third of persons start treatment, and outcomes are often inadequate. Several trials …

In silico drug design strategies for discovering novel tuberculosis therapeutics

CSC Canales, AR Pavan, JL Dos Santos… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Tuberculosis remains a significant concern in global public health due to its
intricate biology and propensity for develo** antibiotic resistance. Discovering new drugs …

[LIVRE][B] WHO operational handbook on tuberculosis. Module 4: treatment-drug-resistant tuberculosis treatment, 2022 update

World Health Organization - 2022 - books.google.com
Operational handbook on tuberculosis. Module 4: Treatment of drug-resistant tuberculosis
treatment, is a derivative product arising from the guideline on the same topic. This …

Mtb-Selective 5-Aminomethyl Oxazolidinone Prodrugs: Robust Potency and Potential Liabilities

HIM Boshoff, K Young, YM Ahn, VD Yadav… - ACS Infectious …, 2024 - ACS Publications
Linezolid is a drug with proven human antitubercular activity whose use is limited to highly
drug-resistant patients because of its toxicity. This toxicity is related to its mechanism of …

Structural toxicity relationship (STR) of linezolid to mitigate myelosuppression and serotonergic toxicity

M Shaikh, H Patel - Bioorganic & Medicinal Chemistry, 2024 - Elsevier
Tuberculosis (TB) remains a significant global health challenge, with “multidrug-resistant
(MDR-TB) and extensively drug-resistant (XDR-TB) strains” posing severe threats to …

Linezolid Dosing and Pharmacokinetics in North American Patients with Tuberculosis

N Maranchick, CA Peloquin… - Clinical Infectious …, 2025 - academic.oup.com
Introduction Linezolid is recommended in treatment regimens for rifampin-or multi-drug-
resistant tuberculosis. However, considerable pharmacokinetic variability exists, and long …

Advancing against drug-resistant tuberculosis: an extensive review, novel strategies and patent landscape

MN Patel, AJ Patel, MN Nandpal, MA Raval… - Naunyn-Schmiedeberg's …, 2024 - Springer
Drug-resistant tuberculosis (DR-TB) represents a pressing global health issue, leading to
heightened morbidity and mortality. Despite extensive research efforts, the escalation of DR …