The three RAS oncogenes make up the most frequently mutated gene family in human
cancer. The well-validated role of mutationally activated RAS genes in driving cancer …

Phosphatidylserine (PtdSer), an essential constituent of eukaryotic membranes, is the most
abundant anionic phospholipid in the eukaryotic cell accounting for up to 10% of the total …

K-Ras is targeted to the plasma membrane by a C-terminal membrane anchor that
comprises a farnesyl-cysteine-methyl-ester and a polybasic domain. We used quantitative …

The highly lethal brain cancer glioblastoma (GBM) poses a daunting challenge because the
blood-brain barrier renders potentially druggable amplified or mutated oncoproteins …

How do Ras isoforms attain oncogenic specificity at the membrane? Oncogenic KRas,
HRas, and NRas (K-Ras, H-Ras, and N-Ras) differentially populate distinct cancers. How …

RAS proteins are small GTPases that regulate signalling networks that control cellular
proliferation and survival. They are frequently mutated in cancer and a commonly occurring …

By serving as intermediaries between cellular metabolism and the bioenergetic demands of
proliferation, endolysosomes allow cancer cells to thrive under normally detrimental …

Sphingolipids in general and ceramides in particular, contribute to pathophysiological
mechanisms by modifying signalling and metabolic pathways. Here, we present the …

Various studies have demonstrated that the two leaflets of cellular membranes interact,
potentially through so-called interdigitation between the fatty acyl groups. While the …

The plasma membrane is uniquely enriched in phosphatidylserine (PtdSer). This anionic
phospholipid is restricted almost exclusively to the inner leaflet of the plasmalemma …