Kappa-opioid receptors (KOR) are widely expressed throughout the central nervous system,
where they modulate a range of physiological processes depending on their location …

Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits
fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop …

The dynorphin/kappa opioid receptor (KOR) system is implicated in the “dark side” of
addiction, in which stress exacerbates maladaptive responses to drug and alcohol …

Pain remains a very pervasive problem throughout medicine. Classical pain management is
achieved through the use of opiates belonging to the mu opioid receptor (MOR) class, which …

The neoclerodane diterpene salvinorin A, found in the leaves of Salvia divinorum, is a potent
κ-opioid receptor agonist, making it an attractive scaffold for development into a treatment for …

Pain continues to be an enormous global health challenge, with millions of new untreated or
inadequately treated patients reported annually. With respect to current clinical applications …

The plant metabolite salvinorin A potently and selectively agonizes the human kappa-opioid
receptor, an emerging target for next-generation analgesics. Here we review analogs of the …

Salvinorin A is a potent hallucinogen, isolated from the ethnomedical plant Salvia divinorum.
Salvinorin A is a selective high efficacy kappa-opioid receptor (KOPr) agonist, and thus …

One of the main challenges in contemporary medicinal chemistry is the development of safer
analgesics, used in the treatment of pain. Currently, moderate to severe pain is still treated …

Biased ligands preferentially activate certain signaling pathways downstream of their target
receptor, leading to differential physiological or behavioral responses downstream. The …