Precision medicine is transforming colorectal cancer treatment through the integration of
advanced technologies and biomarkers, enhancing personalized and effective disease …

Mass spectrometry has revolutionized cell signaling research by vastly simplifying the
analysis of many thousands of phosphorylation sites in the human proteome. Defining the …

Detection of endogenous peptides, especially those with modifications (such as
phosphorylation) in biofluids, can serve as an indicator of intracellular pathophysiology …

Background Gastric cancer is a very common gastrointestinal tumor with a high mortality
rate. Nintedanib has been shown to significantly reduce tumor cell proliferation and increase …

Expression and activity of the AMP-activated protein kinase (AMPK) α 1 catalytic subunit of
the heterotrimeric kinase significantly correlates with poor outcome for colorectal cancer …

Metformin (MET) is an emerging contaminant often found in aquatic environments due to
incompletely metabolized after consumption in the human body, where some of its doses …

Metformin is a widely used drug to treat type II diabetes. Beyond lowering blood sugar, it has
been reported to have pleiotropic effects such as suppressing cancer growth and …

Understanding how proteins in different mammalian tissues are regulated is central to
biology. Protein abundance, turnover, and post-translational modifications like …

Phosphorylation is one of the most important post-translational modifications (PTMs) of
proteins, governing critical protein functions. Most human proteins have been shown to …

Macrophages represent a major immune cell type in tumor microenvironments, they exist in
multiple functional states and are of a strong interest for therapeutic reprogramming. While …