Introduction: Hypertension is caused by increased cardiac output and/or increased
peripheral resistance. Areas covered: The various mechanisms affecting cardiac …

Sustained elevation in the intracellular Ca2+ concentration via Ca2+ influx, which is
activated by a variety of mechanisms, plays a central regulatory role for cardiovascular …

Among cardiovascular diseases, hypertension is one of the main risk factors predisposing to
fatal complications. Oxidative stress and chronic inflammation have been identified as …

Dietary salt plays a major role in the regulation of blood pressure, and the mineralocorticoid
hormone aldosterone controls salt homeostasis and extracellular volume. Recent …

Essential hypertension, a rise in blood pressure of undetermined cause, includes 90% of all
hypertensive cases and is a highly important public health challenge that remains, however …

The regulation of extracellular fluid volume by renal sodium excretion lies at the centre of
blood pressure homeostasis. Renal perfusion pressure can directly regulate sodium …

Hypertension is the most common cardiovascular disease, afflicting> 30% of adults. The
cause of hypertension in most individuals remains unknown,, suggesting that additional …

The goal of the present study was to investigate the functional implications of sexual
dimorphism in the pattern of transporters along the rodent nephron as reported by Veiras et …

Significance: Hepatic ischemia/reperfusion (I/R) injury is an inevitable side effect of major
liver surgery that can culminate in liver failure. The bulk of I/R-induced liver injury results …

Once upon a time, the expression of the epithelial sodium channel (ENaC) was mainly
assigned to the kidneys, colon and sweat glands where it was considered to be the main …