The structure–function relationship of Pseudomonas aeruginosa in infections and its influence on the microenvironment
Pseudomonas aeruginosa is a human pathogen associated with both acute and chronic
infections. While intensively studied, the basic mechanisms enabling the long-term survival …
infections. While intensively studied, the basic mechanisms enabling the long-term survival …
Biofilm antimicrobial susceptibility through an experimental evolutionary lens
Experimental evolution experiments in which bacterial populations are repeatedly exposed
to an antimicrobial treatment, and examination of the genotype and phenotype of the …
to an antimicrobial treatment, and examination of the genotype and phenotype of the …
Cystic fibrosis pathogens persist in the upper respiratory tract following initiation of elexacaftor/tezacaftor/ivacaftor therapy
ABSTRACT Elexacaftor/tezacaftor/ivacaftor (ETI) therapy has revolutionized the treatment of
cystic fibrosis (CF) for most affected individuals but the effects of treatment on sinus …
cystic fibrosis (CF) for most affected individuals but the effects of treatment on sinus …
Metabolic specialization drives reduced pathogenicity in Pseudomonas aeruginosa isolates from cystic fibrosis patients
BH Pedersen, FB Simões, I Pogrebnyakov, M Welch… - Plos …, 2024 - journals.plos.org
Metabolism provides the foundation for all cellular functions. During persistent infections, in
adapted pathogenic bacteria metabolism functions radically differently compared with more …
adapted pathogenic bacteria metabolism functions radically differently compared with more …
Adaptation and evolution of pathogens in the cystic fibrosis lung
PJ Planet - Journal of the Pediatric Infectious Diseases Society, 2022 - academic.oup.com
As opposed to acute respiratory infections, the persistent bacterial infections of the lung that
characterize cystic fibrosis (CF) provide ample time for bacteria to evolve and adapt. The …
characterize cystic fibrosis (CF) provide ample time for bacteria to evolve and adapt. The …
[HTML][HTML] Iron bioavailability regulates Pseudomonas aeruginosa interspecies interactions through type VI secretion expression
The cystic fibrosis (CF) respiratory tract harbors pathogenic bacteria that cause life-
threatening chronic infections. Of these, Pseudomonas aeruginosa becomes increasingly …
threatening chronic infections. Of these, Pseudomonas aeruginosa becomes increasingly …
Microevolution of Pseudomonas aeruginosa in the airways of people with cystic fibrosis
Highlights•Pseudomonas aeruginosa in CF airways: paradigm of bacterial microevolution.•
Evolution within CF host triggers conversions of genotype and phenotype.•Severity of lung …
Evolution within CF host triggers conversions of genotype and phenotype.•Severity of lung …
Pseudomonas aeruginosa faces a fitness trade-off between mucosal colonization and antibiotic tolerance during airway infection
Pseudomonas aeruginosa frequently causes antibiotic-recalcitrant pneumonia, but the
mechanisms driving its adaptation during human infections remain unclear. To reveal the …
mechanisms driving its adaptation during human infections remain unclear. To reveal the …
Intracellular Pseudomonas aeruginosa within the Airway Epithelium of Cystic Fibrosis Lung Tissues
K Malet, E Faure, D Adam, J Donner, L Liu… - American Journal of …, 2024 - atsjournals.org
Rationale: Pseudomonas aeruginosa (Pa) is the major bacterial pathogen colonizing the
airways of adult cystic fibrosis (CF) patients and causes chronic infections that persist …
airways of adult cystic fibrosis (CF) patients and causes chronic infections that persist …
Low diversity and instability of the sinus microbiota over time in adults with cystic fibrosis
Chronic rhinosinusitis (CRS) is a common, yet underreported and understudied
manifestation of upper respiratory disease in people with cystic fibrosis (CF). Recently …
manifestation of upper respiratory disease in people with cystic fibrosis (CF). Recently …