[PDF][PDF] Ductular reaction in liver diseases: pathological mechanisms and translational significances
Ductular reaction (DR) is characterized by the proliferation of reactive bile ducts induced by
liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly …
liver injuries. DR is pathologically recognized as bile duct hyperplasia and is commonly …
Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy
The MET oncogene encodes an unconventional receptor tyrosine kinase with pleiotropic
functions: it initiates and sustains neoplastic transformation when genetically altered …
functions: it initiates and sustains neoplastic transformation when genetically altered …
Circular RNA encoded MET variant promotes glioblastoma tumorigenesis
Activated by its single ligand, hepatocyte growth factor (HGF), the receptor tyrosine kinase
MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and …
MET is pivotal in promoting glioblastoma (GBM) stem cell self-renewal, invasiveness and …
Stem/progenitor cells in liver development, homeostasis, regeneration, and reprogramming
A Miyajima, M Tanaka, T Itoh - Cell stem cell, 2014 - cell.com
The liver is a central organ for homeostasis with unique regenerative capacities. Mature
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …
hepatocytes possess a remarkable capacity to proliferate upon injury, challenging efforts to …
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
miR-122, an abundant liver-specific microRNA (miRNA), regulates cholesterol metabolism
and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in …
and promotes hepatitis C virus (HCV) replication. Reduced miR-122 expression in …
Cancer stem cells in the development of liver cancer
T Yamashita, XW Wang - The Journal of clinical …, 2013 - Am Soc Clin Investig
Liver cancer is an aggressive disease with a poor outcome. Several hepatic stem/progenitor
markers are useful for isolating a subset of liver cells with stem cell features, known as …
markers are useful for isolating a subset of liver cells with stem cell features, known as …
Mechano-modulatory synthetic niches for liver organoid derivation
The recent demonstration that primary cells from the liver can be expanded in vitro as
organoids holds enormous promise for regenerative medicine and disease modelling. The …
organoids holds enormous promise for regenerative medicine and disease modelling. The …
[HTML][HTML] Tissue damage induces a conserved stress response that initiates quiescent muscle stem cell activation
Tissue damage dramatically alters how cells interact with their microenvironment. These
changes in turn dictate cellular responses, such as stem cell activation, yet early cellular …
changes in turn dictate cellular responses, such as stem cell activation, yet early cellular …
[PDF][PDF] Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury
Proliferating ducts, termed “oval cells,” have long been thought to be bipotential, that is,
produce both biliary ducts and hepatocytes during chronic liver injury. The precursor to oval …
produce both biliary ducts and hepatocytes during chronic liver injury. The precursor to oval …
[HTML][HTML] Dipeptidyl peptidase-4: a key player in chronic liver disease
M Itou, T Kawaguchi, E Taniguchi… - World journal of …, 2013 - ncbi.nlm.nih.gov
Abstract Dipeptidyl peptidase-4 (DPP-4) is a membrane-associated peptidase, also known
as CD26. DPP-4 has widespread organ distribution throughout the body and exerts …
as CD26. DPP-4 has widespread organ distribution throughout the body and exerts …