Highlights•Transcriptional feedback is insufficient to account for circadian rhythm
generation.•Post-translational regulators of daily cellular clocks are conserved among …

Circadian clocks have evolved to enable organisms to respond to daily environmental
changes. Maintaining a robust circadian rhythm under various perturbations and stresses is …

Compensation is a defining principle of a true circadian clock, where its approximately 24-
hour period length is relatively unchanged across environmental conditions. Known …

Motivation Time courses utilizing genome scale data are a common approach to identifying
the biological pathways that are controlled by the circadian clock, an important regulator of …

Circadian clock mechanisms have been extensively investigated but the main rate-limiting
step that determines circadian period remains unclear. Formation of a stable complex …

In filamentous fungi, an important kinase responsible for adaptation to changes in available
nutrients is cyclic AMP (cAMP)-dependent protein kinase (protein kinase A [PKA]). This …

Temperature compensation is a fundamental property of all circadian clocks; temperature
compensation results in a relatively constant period length at different physiological …

The fungicide fludioxonil causes hyperactivation of the Hog1p MAPK within the high‐
osmolarity glycerol signaling pathway essential for osmoregulation in pathogenic fungi. The …

Cellulase production in filamentous fungus Trichoderma reesei is highly responsive to
various environmental cues involving multiple positive and negative regulators. XYR1 …

Neurospora crassa is a model organism for the study of circadian clocks, molecular
machineries that confer∼ 24-hr rhythms to different processes at the cellular and organismal …