Therapeutic advances of targeting receptor tyrosine kinases in cancer

C Tomuleasa, AB Tigu, R Munteanu… - … and Targeted Therapy, 2024 - nature.com
Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained
significant clinical attention in oncology due to their central role in cancer pathogenesis …

[HTML][HTML] Artificial intelligence in digital pathology for bladder cancer: hype or hope? A systematic review

F Khoraminia, S Fuster, N Kanwal, M Olislagers… - Cancers, 2023 - mdpi.com
Simple Summary The diagnosis and prediction of prognosis for bladder cancer (BC) can be
challenging because of the subjective nature of pathological evaluation. Artificial …

Choline phosphate-grafted nanozymes as universal extracellular vesicle probes for bladder cancer detection

Q Li, S Zhan, X Yang, Z Zhang, N Sun, X Wang… - ACS …, 2024 - ACS Publications
Urinary extracellular vesicles (uEVs) are regarded as highly promising liquid-biopsy
biomarkers for the early diagnosis and prognosis of bladder cancer (BC). However …

[PDF][PDF] Bladder cancer and artificial intelligence: emerging applications

MA Laurie, SR Zhou, MT Islam, E Shkolyar… - Urologic Clinics of North …, 2024 - Elsevier
AI holds strong potential to guide decision-making for BC diagnosis and treatment and to
integrate such models into the current clinical workflow. This review summarizes the …

Revisiting treatment of metastatic urothelial cancer: where do cisplatin and platinum ineligibility criteria stand?

MJ Moussa, MT Campbell, O Alhalabi - Biomedicines, 2024 - mdpi.com
Cisplatin-based chemotherapy has been the standard of care in metastatic urothelial cancer
(mUC) for more than two decades. However, many patients with comorbidities cannot …

Treatment approaches for FGFR-altered urothelial carcinoma: targeted therapies and immunotherapy

DJ Benjamin, R Hsu - Frontiers in Immunology, 2023 - frontiersin.org
The treatment of metastatic urothelial carcinoma has dramatically changed over the past
decade with the approval of several therapies from multiple drug classes including immune …

Comprehensive Overview of Interface Strategies in Implant Osseointegration

X Lu, Y Zhao, X Peng, C Lu, Z Wu, H Xu… - Advanced Functional …, 2024 - Wiley Online Library
With the improvement of implant design and the expansion of application scenarios,
orthopedic implants have become a common surgical option for treating fractures and end …

Discovery of TYRA-300: first oral selective FGFR3 inhibitor for the treatment of urothelial cancers and achondroplasia

RL Hudkins, E Allen, A Balcer, ID Hoffman… - Journal of Medicinal …, 2024 - ACS Publications
Activating FGFR3 alterations have been identified in up to 15–20% of muscle-invasive
bladder cancer and metastatic urothelial carcinoma (mUC), and as high as 80% in …

The role of TERT C228T and KDM6A alterations and TME in NMIBC treated with BCG

QD **a, JX Sun, ZP Yao, JL Lu, CQ Liu, JZ Xu… - NPJ Precision …, 2024 - nature.com
We aimed to investigate the genomic and tumor microenvironmental (TME) profiles in non-
muscle invasive bladder cancer (NMIBC) and explore potential predictive markers for …

The evolving treatment landscape of metastatic urothelial cancer

G Roviello, M Santoni, GP Sonpavde… - Nature Reviews …, 2024 - nature.com
Cisplatin-based chemotherapy is currently the first-line standard of care for patients with
metastatic urothelial cancer (mUC); however, up to 50% of patients are ineligible for …