Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y **e, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Metabolomics-centered mining of plant metabolic diversity and function: Past decade and future perspectives

S Shen, C Zhan, C Yang, AR Fernie, J Luo - Molecular plant, 2023 - cell.com
Plants are natural experts in organic synthesis, being able to generate large numbers of
specific metabolites with widely varying structures that help them adapt to variable survival …

Impacts of large herbivores on terrestrial ecosystems

RM Pringle, JO Abraham, TM Anderson, TC Coverdale… - Current Biology, 2023 - cell.com
Large herbivores play unique ecological roles and are disproportionately imperiled by
human activity. As many wild populations dwindle towards extinction, and as interest grows …

Advanced methods for natural products discovery: bioactivity screening, dereplication, metabolomics profiling, genomic sequencing, databases and informatic tools …

SP Gaudêncio, E Bayram, L Lukić Bilela, M Cueto… - Marine drugs, 2023 - mdpi.com
Natural Products (NP) are essential for the discovery of novel drugs and products for
numerous biotechnological applications. The NP discovery process is expensive and time …

Medicinal plants meet modern biodiversity science

CC Davis, P Choisy - Current Biology, 2024 - cell.com
Plants have been an essential source of human medicine for millennia. In this review, we
argue that a holistic, interdisciplinary approach to the study of medicinal plants that …

Development of a widely targeted volatilomics method for profiling volatilomes in plants

H Yuan, G Cao, X Hou, M Huang, P Du, T Tan, Y Zhang… - Molecular Plant, 2022 - cell.com
Volatile organic compounds play essential roles in plant environment interactions as well as
determining the fragrance of plants. Although gas chromatography-mass spectrometry …

Plant metabolic gene clusters in the multi-omics era

C Zhan, S Shen, C Yang, Z Liu, AR Fernie… - Trends in Plant …, 2022 - cell.com
Secondary metabolism in plants gives rise to a vast array of small-molecule natural
products. The discovery of operon-like gene clusters in plants has provided a new …

Natural history–guided omics reveals plant defensive chemistry against leafhopper pests

Y Bai, C Yang, R Halitschke, C Paetz, D Kessler… - Science, 2022 - science.org
Although much is known about plant traits that function in nonhost resistance against
pathogens, little is known about nonhost resistance against herbivores, despite its …

[HTML][HTML] Microneedle-based interstitial fluid extraction for drug analysis: Advances, challenges, and prospects

S Ma, J Li, L Pei, N Feng, Y Zhang - Journal of Pharmaceutical Analysis, 2023 - Elsevier
Similar to blood, interstitial fluid (ISF) contains exogenous drugs and biomarkers and may
therefore substitute blood in drug analysis. However, current ISF extraction techniques …

Using synthetic biology to understand the function of plant specialized metabolites

Y Bai, X Liu, IT Baldwin - Annual Review of Plant Biology, 2024 - annualreviews.org
Plant specialized metabolites (PSMs) are variably distributed across taxa, tissues, and
ecological contexts; this variability has inspired many theories about PSM function, which to …