Current trends and challenges in sample preparation for global metabolomics using liquid chromatography–mass spectrometry
D Vuckovic - Analytical and bioanalytical chemistry, 2012 - Springer
The choice of sample-preparation method is extremely important in metabolomic studies
because it affects both the observed metabolite content and biological interpretation of the …
because it affects both the observed metabolite content and biological interpretation of the …
Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies
MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …
developments in molecular analysis, which include important advances in instrumental …
The human serum metabolome
Continuing improvements in analytical technology along with an increased interest in
performing comprehensive, quantitative metabolic profiling, is leading to increased interest …
performing comprehensive, quantitative metabolic profiling, is leading to increased interest …
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
Cancer cells experience higher oxidative stress from reactive oxygen species (ROS) than do
non-malignant cells because of genetic alterations and abnormal growth; as a result …
non-malignant cells because of genetic alterations and abnormal growth; as a result …
Mass-spectrometry-based metabolomics: limitations and recommendations for future progress with particular focus on nutrition research
Mass spectrometry (MS) techniques, because of their sensitivity and selectivity, have
become methods of choice to characterize the human metabolome and MS-based …
become methods of choice to characterize the human metabolome and MS-based …
NMR and pattern recognition methods in metabolomics: from data acquisition to biomarker discovery: a review
Metabolomics is the discipline where endogenous and exogenous metabolites are
assessed, identified and quantified in different biological samples. Metabolites are crucial …
assessed, identified and quantified in different biological samples. Metabolites are crucial …
Metabolite profiling of a NIST Standard Reference Material for human plasma (SRM 1950): GC-MS, LC-MS, NMR, and clinical laboratory analyses, libraries, and web …
Y Simón-Manso, MS Lowenthal, LE Kilpatrick… - Analytical …, 2013 - ACS Publications
Recent progress in metabolomics and the development of increasingly sensitive analytical
techniques have renewed interest in global profiling, ie, semiquantitative monitoring of all …
techniques have renewed interest in global profiling, ie, semiquantitative monitoring of all …
NMR-based metabolomics in human disease diagnosis: applications, limitations, and recommendations
Metabolomics is a dynamic and emerging research field, similar to proteomics,
transcriptomics and genomics in affording global understanding of biological systems. It is …
transcriptomics and genomics in affording global understanding of biological systems. It is …
Inhibition of mitochondrial complex I reverses NOTCH1-driven metabolic reprogramming in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is commonly driven by activating mutations in
NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation …
NOTCH1 that facilitate glutamine oxidation. Here we identify oxidative phosphorylation …
Recommended strategies for spectral processing and post-processing of 1D 1H-NMR data of biofluids with a particular focus on urine
Abstract 1 H NMR spectra from urine can yield information-rich data sets that offer important
insights into many biological and biochemical phenomena. However, the quality and utility …
insights into many biological and biochemical phenomena. However, the quality and utility …