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Activation of retinal glial cells contributes to the degeneration of ganglion cells in experimental glaucoma
Y Miao, GL Zhao, S Cheng, Z Wang, XL Yang - Progress in retinal and eye …, 2023 - Elsevier
Elevation of intraocular pressure (IOP) is a major risk factor for neurodegeneration in
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …
glaucoma. Glial cells, which play an important role in normal functioning of retinal neurons …
Retinal ischemia: mechanisms of damage and potential therapeutic strategies
Retinal ischemia is a common cause of visual impairment and blindness. At the cellular
level, ischemic retinal injury consists of a self-reinforcing destructive cascade involving …
level, ischemic retinal injury consists of a self-reinforcing destructive cascade involving …
Preservation of vision after CaMKII-mediated protection of retinal ganglion cells
Retinal ganglion cells (RGCs) are the sole output neurons that transmit visual information
from the retina to the brain. Diverse insults and pathological states cause degeneration of …
from the retina to the brain. Diverse insults and pathological states cause degeneration of …
Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond
Neuroprotective drugs tested in clinical trials, particularly those that block N-methyl-d-
aspartate-sensitive glutamate receptors (NMDARs), have failed miserably in large part …
aspartate-sensitive glutamate receptors (NMDARs), have failed miserably in large part …
Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist—a review of preclinical data
CG Parsons, W Danysz, G Quack - Neuropharmacology, 1999 - Elsevier
N-methyl-d-aspartate (NMDA) receptor antagonists have therapeutic potential in numerous
CNS disorders ranging from acute neurodegeneration (eg stroke and trauma), chronic …
CNS disorders ranging from acute neurodegeneration (eg stroke and trauma), chronic …
Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …
Regulation of retinal blood flow in health and disease
CJ Pournaras, E Rungger-Brändle, CE Riva… - Progress in retinal and …, 2008 - Elsevier
Optimal retinal neuronal cell function requires an appropriate, tightly regulated environment,
provided by cellular barriers, which separate functional compartments, maintain their …
provided by cellular barriers, which separate functional compartments, maintain their …
Failures and successes of NMDA receptor antagonists: molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic …
Excitotoxicity, defined as excessive exposure to the neurotransmitter glutamate or
overstimulation of its membrane receptors, has been implicated as one of the key factors …
overstimulation of its membrane receptors, has been implicated as one of the key factors …
Neuroprotective strategies for retinal ganglion cell degeneration: current status and challenges ahead
The retinal ganglion cells (RGCs) are the output cells of the retina into the brain. In
mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving …
mammals, these cells are not able to regenerate their axons after optic nerve injury, leaving …
The chemical biology of clinically tolerated NMDA receptor antagonists
Most neuroprotective drugs have failed in clinical trials because of side‐effects, causing
normal brain function to become compromised. A case in point concerns antagonists of the …
normal brain function to become compromised. A case in point concerns antagonists of the …