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Melatonin membrane receptors in peripheral tissues: distribution and functions
Many of melatonin's actions are mediated through interaction with the G-protein coupled
membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or …
membrane bound melatonin receptors type 1 and type 2 (MT1 and MT2, respectively) or …
Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science
The presence of melatonin in plants is universal. Evidence has confirmed that a major
portion of the melatonin is synthesized by plants themselves even though a homologue of …
portion of the melatonin is synthesized by plants themselves even though a homologue of …
Melatonin in humans
A Brzezinski - New England journal of medicine, 1997 - Mass Medical Soc
Three centuries ago, the French philosopher René Descartes described the pineal gland as
“the seat of the soul,” but it was not until the late 1950s that melatonin, the principal …
“the seat of the soul,” but it was not until the late 1950s that melatonin, the principal …
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors
Abstract The hormone melatonin (5-methoxy-N-acetyltryptamine) is synthesized primarily in
the pineal gland and retina, and in several peripheral tissues and organs. In the circulation …
the pineal gland and retina, and in several peripheral tissues and organs. In the circulation …
Physiological effects of melatonin: role of melatonin receptors and signal transduction pathways
SR Pandi-Perumal, I Trakht, V Srinivasan… - Progress in …, 2008 - Elsevier
Melatonin, an endogenous signal of darkness, is an important component of the body's
internal time-kee** system. As such it regulates major physiological processes including …
internal time-kee** system. As such it regulates major physiological processes including …
Functional MT1 and MT2 melatonin receptors in mammals
Melatonin, dubbed the hormone of darkness, is known to regulate a wide variety of
physiological processes in mammals. This review describes well-defined functional …
physiological processes in mammals. This review describes well-defined functional …
Cellular mechanisms of melatonin action
J Vanecek - Physiological reviews, 1998 - journals.physiology.org
Vanecek, Jiri. Cellular Mechanisms of Melatonin Action. Physiol. Rev. 78: 687–721, 1998.—
The pineal hormone melatonin is involved in photic regulations of various kinds, including …
The pineal hormone melatonin is involved in photic regulations of various kinds, including …
Melatonin receptors in humans: biological role and clinical relevance
C Ekmekcioglu - Biomedicine & Pharmacotherapy, 2006 - Elsevier
In addition to its antioxidative effects melatonin acts through specific nuclear and plasma
membrane receptors. To date, two G-protein coupled melatonin membrane receptors, MT1 …
membrane receptors. To date, two G-protein coupled melatonin membrane receptors, MT1 …
Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance.
AB Dollins, IV Zhdanova, RJ Wurtman… - Proceedings of the …, 1994 - pnas.org
We examined effects of very low doses of melatonin (0.1-10 mg, orally) or placebo,
administered at 1145 h, on sleep latency and duration, mood, performance, oral …
administered at 1145 h, on sleep latency and duration, mood, performance, oral …
[PDF][PDF] Molecular pharmacology, regulation and function of mammalian melatonin receptors
Introduction 3. Melatonin receptors 3.1. MT1 and MT2 melatonin receptors 3.1. 1. Molecular
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …