Viruses are highly dependent on the host they infect. Their dependence triggers processes
of virus–host co-adaptation, enabling viruses to explore host resources whilst esca** …

One of the core standards of biochemistry is that the function of a protein relies on its 3D
structure. This idea posits that all the information required for a protein to perform its …

ABSTRACT RNA viruses that replicate in the cell cytoplasm typically concentrate their
replication machinery within specialized compartments. This concentration favors enzymatic …

In recent years, protein science has been revolutionized by the discovery of intrinsically
disordered proteins (IDPs). In contrast to the classical paradigm that a given protein …

Small-angle X-ray scattering (SAXS) is a robust technique for the comprehensive structural
characterizations of biological macromolecular complexes in solution. Here, we present a …

Newcastle disease virus (NDV) belongs to Paramyxoviridae, which contains lethal human
and animal pathogens. NDV RNA genome is replicated and transcribed by a multifunctional …

Intrinsically disordered proteins (IDPs) possess the property of inherent flexibility and can be
distinguished from other proteins in terms of lack of any fixed structure. Such dynamic …

Nipah virus (NiV) is a highly pathogenic emergent paramyxovirus causing deadly
encephalitis in humans. Its replication requires a constant supply of unassembled …

Non-segmented negative strand (NNS) RNA viruses belonging to the order
Mononegavirales are highly diversified eukaryotic viruses including significant human …

Highlights•Comparative structure and function analysis of RNA synthesis machinery of
negative-sense RNA viruses.•Unique biology of mRNA cap**: cap snatching versus cap …