Melanoma skin cancer is derived from skin melanocytes and has a high risk of metastatic
spread. Many clinical attributes and risk factors associated with melanoma have been well …

Despite huge efforts made in academic and pharmaceutical worldwide research, current
anticancer therapies achieve effective treatment in a limited number of neoplasia cases only …

The clinical use of molecular targeted therapy is rapidly evolving but has primarily focused
on genomic alterations. Transcriptomic analysis offers an opportunity to dissect the …

Skin cutaneous melanoma (SKCM) is a chronically malignant tumor with a high mortality
rate. Pyroptosis, a kind of pro-inflammatory programmed cell death, has been linked to …

Immunotherapy has demonstrated the potential to cure melanoma, while the current
response rate is still unsatisfactory in clinics. Extensive evidence indicates the correlation …

Next-generation sequencing refers to a high-throughput technology that determines the
nucleic acid sequences and identifies variants in a sample. The technology has been …

Cutaneous malignant melanoma is an aggressive cancer of melanocytes with a strong
propensity to metastasize. We posit that melanoma cells acquire metastatic capability by …

It has been posited that anti-tumoral innate activation is driven by derepression of
endogenous repeats. We compared RNA sequencing protocols to assess repeat …

Background Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It
is greatly important to identify prognostic biomarkers to guide the clinical management …

Asthma is a common, under-diagnosed disease affecting all ages. We sought to identify a
nasal brush-based classifier of mild/moderate asthma. 190 subjects with mild/moderate …