The multiple mechanisms that regulate p53 activity and cell fate
A Hafner, ML Bulyk, A Jambhekar… - Nature reviews Molecular …, 2019 - nature.com
The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
p53 modifications: exquisite decorations of the powerful guardian
The last 40 years have witnessed how p53 rose from a viral binding protein to a central
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …
factor in both stress responses and tumor suppression. The exquisite regulation of p53 …
Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease
Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …
p53 acetylation: regulation and consequences
SM Reed, DE Quelle - Cancers, 2014 - mdpi.com
Post-translational modifications of p53 are critical in modulating its tumor suppressive
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …
functions. Ubiquitylation, for example, plays a major role in dictating p53 stability, subcellular …
SET for life: biochemical activities and biological functions of SET domain-containing proteins
SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …
The functional diversity of protein lysine methylation
S Lanouette, V Mongeon, D Figeys… - Molecular systems …, 2014 - embopress.org
Large‐scale characterization of post‐translational modifications (PTM s), such as
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …
Lysine methylation: beyond histones
Posttranslational modifications (PTMs) of histone proteins, such as acetylation, methylation,
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …
phosphorylation, and ubiquitylation, play essential roles in regulating chromatin dynamics …
A methylation-phosphorylation switch determines Sox2 stability and function in ESC maintenance or differentiation
Sox2 is a key factor for maintaining embryonic stem cell (ESS) pluripotency, but little is
known about its posttranslational regulation. Here we present evidence that the precise level …
known about its posttranslational regulation. Here we present evidence that the precise level …
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells
SET domain containing (lysine methyltransferase) 7 (SETD7) is implicated in multiple
signaling and disease related pathways with a broad diversity of reported substrates. Here …
signaling and disease related pathways with a broad diversity of reported substrates. Here …
Emerging roles of lysine methylation on non-histone proteins
Lysine methylation is a common posttranslational modification (PTM) of histones that is
important for the epigenetic regulation of transcription and chromatin in eukaryotes …
important for the epigenetic regulation of transcription and chromatin in eukaryotes …