RNAs fold into 3D structures that range from simple helical elements to complex tertiary
structures and quaternary ribonucleoprotein assemblies. The functions of many regulatory …

This review describes off-resonance R 1ρ relaxation dispersion NMR methods for
characterizing microsecond-to-millisecond chemical exchange in uniformly 13 C/15 N …

O-Methyl (Nm) is a highly abundant post-transcriptional RNA modification that plays
important biological roles through mechanisms that are not entirely understood. There is …

Sparse and short-lived excited RNA conformational states are essential players in cell
physiology, disease, and therapeutic development, yet determining their 3D structures …

An ever‐increasing number of functional RNAs require a mechanistic understanding. RNA
function relies on changes in its structure, so‐called dynamics. To reveal dynamic processes …

The implication of RNA in multiple cellular processes beyond protein coding has revitalized
interest in the development of small molecules for therapeutically targeting RNA and for …

RNA molecules, in one form or another, are involved in almost all aspects of cell physiology,
as well as in disease development. The diversity of the functional roles of RNA comes from …

RNA recognition frequently results in conformational changes that optimize intermolecular
binding. As a consequence, the overall binding affinity of RNA to its binding partners …

Small molecules and short peptides that potently and selectively bind RNA are rare, making
the molecular structures of these complexes highly exceptional. Accordingly, several recent …

Low-abundance short-lived non-native conformations referred to as excited states (ESs) are
increasingly observed in vitro and implicated in the folding and biological activities of …