Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Pathophysiology of cardiac hypertrophy and heart failure: signaling pathways and novel therapeutic targets
The onset of heart failure is typically preceded by cardiac hypertrophy, a response of the
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …
heart to increased workload, a cardiac insult such as a heart attack or genetic mutation …
The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy
Background: N 6-Methyladenosine (m6A) methylation is the most prevalent internal
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …
posttranscriptional modification on mammalian mRNA. The role of m6A mRNA methylation …
Skeletal muscle remodeling in response to eccentric vs. concentric loading: morphological, molecular, and metabolic adaptations
Skeletal muscle contracts either by shortening or lengthening (concentrically or
eccentrically, respectively); however, the two contractions substantially differ from one …
eccentrically, respectively); however, the two contractions substantially differ from one …
Physiological and pathological cardiac hypertrophy
I Shimizu, T Minamino - Journal of molecular and cellular cardiology, 2016 - Elsevier
The heart must continuously pump blood to supply the body with oxygen and nutrients. To
maintain the high energy consumption required by this role, the heart is equipped with …
maintain the high energy consumption required by this role, the heart is equipped with …
Molecular basis of physiological heart growth: fundamental concepts and new players
The heart hypertrophies in response to developmental signals as well as increased
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …
workload. Although adult-onset hypertrophy can ultimately lead to disease, cardiac …
mRNA modifications in cardiovascular biology and disease: with a focus on m6A modification
Among several known RNA modifications, N6‐methyladenosine (m6A) is the most studied
RNA epitranscriptomic modification and controls multiple cellular functions during …
RNA epitranscriptomic modification and controls multiple cellular functions during …
Muscle thickness correlates to muscle cross‐sectional area in the assessment of strength training‐induced hypertrophy
Muscle thickness (MT) measured by ultrasound has been used to estimate cross‐sectional
area (measured by CT and MRI) at a single time point. We tested whether MT could be used …
area (measured by CT and MRI) at a single time point. We tested whether MT could be used …
Methods in cardiomyocyte isolation, culture, and gene transfer
WE Louch, KA Sheehan, BM Wolska - Journal of molecular and cellular …, 2011 - Elsevier
Since techniques for cardiomyocyte isolation were first developed 35years ago, experiments
on single myocytes have yielded great insight into their cellular and sub-cellular physiology …
on single myocytes have yielded great insight into their cellular and sub-cellular physiology …
Architectural, functional and molecular responses to concentric and eccentric loading in human skeletal muscle
Aim We investigated architectural, functional and molecular responses of human skeletal
muscle to concentric (CON) or eccentric (ECC) resistance training (RT). Methods Twelve …
muscle to concentric (CON) or eccentric (ECC) resistance training (RT). Methods Twelve …