How distal cis-regulatory elements (eg, enhancers) communicate with promoters remains an
unresolved question of fundamental importance. Although transcription factors and cofactors …

Technological advances in genomics and imaging have led to an explosion of molecular
and cellular profiling data from large numbers of samples. This rapid increase in biological …

Enhancer elements in the human genome control how genes are expressed in specific cell
types and harbor thousands of genetic variants that influence risk for common diseases …

Abstract The Cistrome Data Browser (DB) is a resource of human and mouse cis-regulatory
information derived from ChIP-seq, DNase-seq and ATAC-seq chromatin profiling assays …

Gene regulatory elements are central drivers of phenotypic variation and thus of critical
importance towards understanding the genetics of complex traits. The Functional Annotation …

The field of machine learning, which aims to develop computer algorithms that improve with
experience, holds promise to enable computers to assist humans in the analysis of large …

Pivotal to projecting the fate of coral reefs is the capacity of reef-building corals to
acclimatize and adapt to climate change. Transgenerational plasticity may enable some …

Chromatin features are widely used for genome-scale map** of enhancers. However,
discriminating active enhancers from other cis-regulatory elements, predicting enhancer …

Monomethylation of histone H3 at lysine 4 (H3K4me1) and acetylation of histone H3 at
lysine 27 (H3K27ac) are correlated with transcriptionally engaged enhancer elements, but …

Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a central method in
epigenomic research. Genome-wide analysis of histone modifications, such as enhancer …