Runt-related transcription factor 2 (RUNX2) is a transcription factor closely associated with
the osteoblast phenotype. While frequently referred to, the complexity of its regulation and its …

Blood development in Drosophila melanogaster shares several interesting features with
hematopoiesis in vertebrates, including spatiotemporal regulation as well as the use of …

Osteoarthritis (OA) is a degenerative joint disease that involves the destruction of articular
cartilage and eventually leads to disability. Molecules that promote the selective …

Biological systems involving short-range activators and long-range inhibitors can generate
complex patterns. Reaction-diffusion models postulate that differences in signaling range …

Runx2/Cbfa1 has been identified as a “master gene” controlling osteoblast differentiation.
However, its role in inducing the osteoblast phenotype has been characterized primarily in …

The runt box (Runx) is a highly conserved DNA binding and protein—protein interaction
domain that defines a family of heterodimeric transcription factors with essential roles in …

Transcription factors have traditionally been viewed with skepticism as viable drug targets,
but they offer the potential for completely novel mechanisms of action that could more …

Acute myeloid leukemia (AML) is the most common form of adult leukemia. The transcription
factor fusion CBFβ-SMMHC (core binding factor β and the smooth-muscle myosin heavy …

The RUNX1 transcription factor has recently been shown to be obligatory for normal
development. RUNX1 controls the expression of genes essential for proper development in …

Background Transforming growth factor beta (TGFβ), a multifunctional cytokine, plays a
crucial role in the accumulation of extracellular matrix components in lung fibrosis, where …