Toward multi-targeted platinum and ruthenium drugs—a new paradigm in cancer drug treatment regimens?

RG Kenny, CJ Marmion - Chemical reviews, 2019 - ACS Publications
While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

What blocks more anticancer platinum complexes from experiment to clinic: Major problems and potential strategies from drug design perspectives

K Peng, BB Liang, W Liu, ZW Mao - Coordination Chemistry Reviews, 2021 - Elsevier
Encouraged by the worldwide success of cisplatin in the field of cancer chemotherapy,
intensive works have been conducted to explore more platinum coordination complexes as …

Simultaneous Photoactivation of cGAS‐STING Pathway and Pyroptosis by Platinum (II) Triphenylamine Complexes for Cancer Immunotherapy

YY Ling, XY **a, L Hao, WJ Wang, H Zhang… - Angewandte …, 2022 - Wiley Online Library
Activation of the cyclic GMP‐AMP synthase‐stimulator of the interferon gene (cGAS‐STING)
pathway is a potent anticancer immunotherapeutic strategy, and the induction of pyroptosis …

Recent advances in the synthesis, stability, and activation of platinum (IV) anticancer prodrugs

Z Xu, Z Wang, Z Deng, G Zhu - Coordination Chemistry Reviews, 2021 - Elsevier
Platinum-based anticancer drugs have been widely applied in clinical settings for more than
40 years. The remarkable breakthroughs that have come from the use of these complexes in …

A photocaged, water-oxidizing, and nucleolus-targeted Pt (IV) complex with a distinct anticancer mechanism

Z Deng, N Wang, Y Liu, Z Xu, Z Wang… - Journal of the …, 2020 - ACS Publications
Targeted anticancer prodrugs that can be controllably activated are highly desired for
personalized precision medicine in cancer therapy. Such prodrugs with unique action …

Fighting against drug‐resistant tumors using a dual‐responsive Pt (IV)/Ru (II) bimetallic polymer

X Zeng, Y Wang, J Han, W Sun, HJ Butt… - Advanced …, 2020 - Wiley Online Library
Drug resistance is a major problem in cancer treatment. Herein, the design of a dual‐
responsive Pt (IV)/Ru (II) bimetallic polymer (PolyPt/Ru) to treat cisplatin‐resistant tumors in …

Advances in multiple stimuli-responsive drug-delivery systems for cancer therapy

R Jia, L Teng, L Gao, T Su, L Fu, Z Qiu… - International journal of …, 2021 - Taylor & Francis
Nanomedicines afford unique advantages in therapeutic intervention against tumors.
However, conventional nanomedicines have failed to achieve the desired effect against …

Platinum coordination compounds with potent anticancer activity

KM Deo, DL Ang, B McGhie, A Rajamanickam… - Coordination Chemistry …, 2018 - Elsevier
Many international researchers have strived to understand the mechanism of action or
improve the efficacy of inorganic coordination compounds that have been identified to …

Platinum (IV) antitumor complexes and their nano-drug delivery

C Jia, GB Deacon, Y Zhang, C Gao - Coordination Chemistry Reviews, 2021 - Elsevier
Platinum-based anticancer drugs dominate the chemotherapy field for several cancers, but
problems such as systemic toxicity and acquired resistance for some primary tumors hamper …

Bimetallic nanoplatforms for prostate cancer treatment by interfering cellular communication

S Zhang, X Ji, Z Liu, Z **e, Y Wang… - Journal of the …, 2024 - ACS Publications
Cellular communication mediated by messenger molecules plays an important role in the
progression of cancer. Herein, pH-sensitive zeolitic imidazolate framework-8 (ZIF-8) loaded …