In this review, we comprehensively present the function of epigenetic regulations in normal
placental development as well as in a prominent disease of placental origin, preeclampsia …

It is thought that germ cells and preimplantation embryos during development are most
susceptible to endogenous and exogenous environmental factors because the epigenome …

Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also
over larger genomic regions. In most human tissues, the vast majority of the genome is …

Background DNA methylation (DNAm) profiling has emerged as a powerful tool for
characterizing the placental methylome. However, previous studies have focused primarily …

Preeclampsia is a disease of the mother, fetus, and placenta, and the gaps in our
understanding of the complex interactions among their respective disease pathways …

Objectives Socioeconomic status (SES) is a powerful determinant of health, but the
underlying biological mechanisms are poorly understood. This study investigates whether …

Chronic inflammation contributes to a wide range of human diseases, and environments in
infancy and childhood are important determinants of inflammatory phenotypes. The …

DNA methylation in repetitive elements (RE) suppresses their mobility and maintains
genomic stability, and decreases in it are frequently observed in tumor and/or surrogate …

Exposure to environmental contaminants during pregnancy has been linked to adverse
outcomes at birth and later in life. The link between prenatal exposures and latent health …

The placenta guides fetal growth and development. Bisphenol A (BPA) and phthalates are
widespread environmental contaminants and endocrine disruptors, and the placental …