Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Depression is one of the most prevalent and life-threatening forms of mental illnesses,
whereas Alzheimer's disease is a neurodegenerative disorder that affects more than 37 …

Clarifying the relationships between neuropsychiatric symptoms and Alzheimer's disease
(AD)-related pathology may open avenues for effective treatments. Here, we investigate the …

BACE1 activity is significantly increased in the brains of Alzheimer's disease patients,
potentially contributing to neurodegeneration. The voltage-gated sodium channel (Nav1) β2 …

Tauopathies are neurodegenerative disorders characterized by the accumulation of
abnormal tau protein leading to cognitive and/or motor dysfunction. To understand the …

Serotonin (5-HT) plays an important role in the regulation of several basic functions of the
central and peripheral nervous system. Among the 5-HT receptors, serotonin-6 (5-HT6) …

Objective: Neuropsychiatric symptoms (NPS) may be the first manifestation of an underlying
neurocognitive disorder. We undertook a review to provide an update on the epidemiology …

Muscarinic acetylcholine receptors (mAChRs) have long been viewed as viable targets for
novel therapeutic agents for the treatment of Alzheimer's disease (AD) and other disorders …

Alzheimer's disease (AD) is the principal neurodegenerative pathology in the world
displaying negative impacts on both the health and social ability of patients and inducing …

Depression is a neuropsychiatric disorder affecting a huge percentage of the active
population especially in developed countries. Research has devoted much of its attention to …