Desmodium styracifolium: Botanical and ethnopharmacological insights, phytochemical investigations, and prospects in pharmacology and pharmacotherapy

V Opryshko, A Prokhach, O Akimov, M Riabushko… - Heliyon, 2024‏ - cell.com
The purpose of this inquiry is to provide a conprehensive summary and analysis of the
literature concerning the pharmacological properties of components that can be extracted …

Effects and medical application of plant-origin polyphenols: A narrative review

G Janigashvili, I Chkhikvishvili, L Ratiani… - Bioactive Compounds in …, 2024‏ - ffhdj.com
The impact of oxidative stress in the pathogenesis of various diseases is well known.
Oxidative stress occurs when there is an imbalance between the production of reactive …

Antioxidant and wound healing bioactive potential of extracts obtained from bark and needles of softwood species

EI Geana, CT Ciucure, R Tamaian, IC Marinas… - Antioxidants, 2023‏ - mdpi.com
Interest in the extraction of phytochemical bioactive compounds, especially polyphenols
from biomass, has recently increased due to their valuable biological potential as natural …

[HTML][HTML] Unraveling the parahormetic mechanism underlying the health-protecting effects of grapeseed procyanidins

G Baron, A Altomare, L Della Vedova, F Gado… - Redox Biology, 2024‏ - Elsevier
Proanthocyanidins (PACs), the predominant constituents within Grape Seed Extract (GSE),
are intricate compounds composed of interconnected flavan-3-ol units. Renowned for their …

[HTML][HTML] Molecular mechanisms and potential applications of chondroitin sulphate in managing post-traumatic osteoarthritis

I Golovach, D Rekalov, Y Akimov, H Kostenko… - …, 2023‏ - ncbi.nlm.nih.gov
Abstract Post-traumatic osteoarthritis (PTOA), a disorder of the synovium, subchondral bone,
and cartilage that affects the entire joint, constitutes approximately 12% of all cases of …

[HTML][HTML] Understanding the molecular bridges between the drugs and immune cell

UC Dash, V Nayak, HS Navani, RR Samal… - Pharmacology & …, 2025‏ - Elsevier
The interactions of drugs with the host's immune cells determine the drug's efficacy and
adverse effects in patients. Nonsteroidal Anti-Inflammatory Drugs (NSAID), such as …

Chondroitin sulfate in osteoarthritis management among diabetic patients: molecular mechanisms and clinical potential

O Kuryata, O Akimov, S Denisenko… - Romanian Journal of …, 2023‏ - rjdnmd.org
Osteoarthritis and type 2 diabetes mellitus are two prevalent chronic conditions that impose
a substantial burden on healthcare systems worldwide. The comorbidity of type 2 diabetes …

Caveolae and caveolin-1 as targets of dietary polyphenols for protection against vascular endothelial dysfunction

J Terao - Journal of Clinical Biochemistry and Nutrition, 2024‏ - pmc.ncbi.nlm.nih.gov
Caveolae, consisting of caveolin-1 proteins, are ubiquitously present in endothelial cells and
contribute to normal cardiovascular functions by acting as a platform for cellular signaling …

Therapeutic potential of 5-aminolevulinic acid in metabolic disorders: Current insights and future directions

O Kuryata, O Akimov, M Riabushko, H Kostenko… - iScience, 2024‏ - cell.com
Aminolevulinic acid (5-ALA) is an essential compound in the biosynthesis of heme, playing a
critical role in various physiological processes within the human body. This review provides …

Effectiveness of the use of bioactive concentrate of marine fish in patients with back pain

MM Oros, NI Fister, OY Akimov… - PAIN, JOINTS …, 2024‏ - pjs.zaslavsky.com.ua
Background. The urgency of pain relief and patient improvement necessitates evaluating the
most effective treatment approaches. This includes a comparative analysis of medications …