An unprecedented revolution in medicinal chemistry driven by the progress of biological science
KC Chou - Current topics in medicinal chemistry, 2017 - ingentaconnect.com
The eternal or ultimate goal of medicinal chemistry is to find most effective ways to treat
various diseases and extend human beings' life as long as possible. Human being is a …
various diseases and extend human beings' life as long as possible. Human being is a …
Advances in predicting subcellular localization of multi-label proteins and its implication for develo** multi-target drugs
KC Chou - Current medicinal chemistry, 2019 - ingentaconnect.com
The smallest unit of life is a cell, which contains numerous protein molecules. Most of the
functions critical to the cell's survival are performed by these proteins located in its different …
functions critical to the cell's survival are performed by these proteins located in its different …
pSuc-Lys: predict lysine succinylation sites in proteins with PseAAC and ensemble random forest approach
Being one type of post-translational modifications (PTMs), protein lysine succinylation is
important in regulating varieties of biological processes. It is also involved with some …
important in regulating varieties of biological processes. It is also involved with some …
iSuc-PseOpt: identifying lysine succinylation sites in proteins by incorporating sequence-coupling effects into pseudo components and optimizing imbalanced training …
Succinylation is a posttranslational modification (PTM) where a succinyl group is added to a
Lys (K) residue of a protein molecule. Lysine succinylation plays an important role in …
Lys (K) residue of a protein molecule. Lysine succinylation plays an important role in …
[HTML][HTML] Pse-in-One 2.0: an improved package of web servers for generating various modes of pseudo components of DNA, RNA, and protein sequences
B Liu, H Wu, KC Chou - Natural science, 2017 - scirp.org
Pse-in-One 2.0 is a package of web-servers evolved from Pse-in-One (Liu, B., Liu, F., Wang,
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
X., Chen, J. Fang, L. & Chou, KC Nucleic Acids Research, 2015, 43: W65-W71). In order to …
iPhos‐PseEvo: identifying human phosphorylated proteins by incorporating evolutionary information into general PseAAC via grey system theory
Protein phosphorylation plays a critical role in human body by altering the structural
conformation of a protein, causing it to become activated/deactivated, or functional …
conformation of a protein, causing it to become activated/deactivated, or functional …
Progresses in predicting post-translational modification
KC Chou - International Journal of Peptide Research and …, 2020 - Springer
Identification of the sites of post-translational modifications (PTMs) in protein, RNA, and DNA
sequences is currently a very hot topic. This is because the information thus obtained is very …
sequences is currently a very hot topic. This is because the information thus obtained is very …
pLoc_bal-mVirus: predict subcellular localization of multi-label virus proteins by Chou's general PseAAC and IHTS treatment to balance training dataset
X **ao, X Cheng, G Chen, QI Mao… - Medicinal …, 2019 - ingentaconnect.com
Background/Objective: Knowledge of protein subcellular localization is vitally important for
both basic research and drug development. Facing the avalanche of protein sequences …
both basic research and drug development. Facing the avalanche of protein sequences …
Proposing pseudo amino acid components is an important milestone for proteome and genome analyses
KC Chou - International Journal of Peptide Research and …, 2020 - Springer
In this minireview paper it has been elucidated that the proposal of pseudo amino acid
components represents a very important milestone for the disciplines of proteome and …
components represents a very important milestone for the disciplines of proteome and …
[HTML][HTML] WITHDRAWN: An insightful recollection for predicting protein subcellular locations in multi-label systems
KC Chou - 2019 - Elsevier
WITHDRAWN: An insightful recollection for predicting protein subcellular locations in multi-label
systems - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …
systems - ScienceDirect Skip to main contentSkip to article Elsevier logo Journals & Books …